Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids

Detalhes bibliográficos
Autor(a) principal: Arvand,Majid
Data de Publicação: 2012
Outros Autores: Hashemi,Masoumeh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000300004
Resumo: A potentiometric chemosensor for selective determination of sertraline was developed based on the molecular imprinting technique. The molecularly imprinted polymer was synthesized by precipitation polymerization, using sertraline hydrochloride as a template molecule, methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. The sensor was developed by dispersing the sertraline imprinted polymer particles in dibutyl sebacate plasticizer and embedding in poly(vinyl chloride) matrix. Characteristics of the proposed sensor were evaluated by measuring the potential response to sertraline hydrochloride in the range from 1.0 µmol L-1 to 10 mmol L-1 with a near Nernstian response of 57.7 mV decade-1 and a limit of detection of 0.8 µmol L-1. The potentiometric selectivity coefficients of the proposed sensor were evaluated and it exhibited good selectivity to sertraline with respect to the other antidepressants. It was used as indicator electrode in potentiometric determination of sertraline in tablets and biological fluids.
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spelling Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluidsmolecularly imprinted polymersprecipitation polymerizationsertralinepotentiometrybiological fluidsA potentiometric chemosensor for selective determination of sertraline was developed based on the molecular imprinting technique. The molecularly imprinted polymer was synthesized by precipitation polymerization, using sertraline hydrochloride as a template molecule, methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. The sensor was developed by dispersing the sertraline imprinted polymer particles in dibutyl sebacate plasticizer and embedding in poly(vinyl chloride) matrix. Characteristics of the proposed sensor were evaluated by measuring the potential response to sertraline hydrochloride in the range from 1.0 µmol L-1 to 10 mmol L-1 with a near Nernstian response of 57.7 mV decade-1 and a limit of detection of 0.8 µmol L-1. The potentiometric selectivity coefficients of the proposed sensor were evaluated and it exhibited good selectivity to sertraline with respect to the other antidepressants. It was used as indicator electrode in potentiometric determination of sertraline in tablets and biological fluids.Sociedade Brasileira de Química2012-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000300004Journal of the Brazilian Chemical Society v.23 n.3 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012000300004info:eu-repo/semantics/openAccessArvand,MajidHashemi,Masoumeheng2012-04-04T00:00:00Zoai:scielo:S0103-50532012000300004Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-04-04T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids
title Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids
spellingShingle Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids
Arvand,Majid
molecularly imprinted polymers
precipitation polymerization
sertraline
potentiometry
biological fluids
title_short Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids
title_full Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids
title_fullStr Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids
title_full_unstemmed Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids
title_sort Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids
author Arvand,Majid
author_facet Arvand,Majid
Hashemi,Masoumeh
author_role author
author2 Hashemi,Masoumeh
author2_role author
dc.contributor.author.fl_str_mv Arvand,Majid
Hashemi,Masoumeh
dc.subject.por.fl_str_mv molecularly imprinted polymers
precipitation polymerization
sertraline
potentiometry
biological fluids
topic molecularly imprinted polymers
precipitation polymerization
sertraline
potentiometry
biological fluids
description A potentiometric chemosensor for selective determination of sertraline was developed based on the molecular imprinting technique. The molecularly imprinted polymer was synthesized by precipitation polymerization, using sertraline hydrochloride as a template molecule, methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. The sensor was developed by dispersing the sertraline imprinted polymer particles in dibutyl sebacate plasticizer and embedding in poly(vinyl chloride) matrix. Characteristics of the proposed sensor were evaluated by measuring the potential response to sertraline hydrochloride in the range from 1.0 µmol L-1 to 10 mmol L-1 with a near Nernstian response of 57.7 mV decade-1 and a limit of detection of 0.8 µmol L-1. The potentiometric selectivity coefficients of the proposed sensor were evaluated and it exhibited good selectivity to sertraline with respect to the other antidepressants. It was used as indicator electrode in potentiometric determination of sertraline in tablets and biological fluids.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000300004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000300004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532012000300004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.23 n.3 2012
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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