Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity

Detalhes bibliográficos
Autor(a) principal: Amaral,Patricia de A.
Data de Publicação: 2009
Outros Autores: Petrignet,Julien, Gouault,Nicolas, Agustini,Taciane, Lohézic-Ledévéhat,Françoise, Cariou,Alexandre, Grée,René, Eifler-Lima,Vera L., David,Michèle
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000900018
Resumo: Palladium-catalyzed cross coupling reactions (Sonogashira-Hagihara, Suzuki-Miyaura, and Heck) coupling and nickel hydride-mediated tandem isomerization aldolisation have been used for the synthesis of three series of δ-valerolactones substituted in positions 3, 4, 5 and 6 of the lactone ring. The 26 kavaïn-like derivatives were tested against three cell lines and five of them exhibited a weak cytotoxic activity.
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spelling Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activityδ-valerolactoneskavaïn analoguesHeckSonogashira-HagiharaSuzuki-Miyauratandem isomerization-aldolizationcytotoxicityPalladium-catalyzed cross coupling reactions (Sonogashira-Hagihara, Suzuki-Miyaura, and Heck) coupling and nickel hydride-mediated tandem isomerization aldolisation have been used for the synthesis of three series of δ-valerolactones substituted in positions 3, 4, 5 and 6 of the lactone ring. The 26 kavaïn-like derivatives were tested against three cell lines and five of them exhibited a weak cytotoxic activity.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000900018Journal of the Brazilian Chemical Society v.20 n.9 2009reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532009000900018info:eu-repo/semantics/openAccessAmaral,Patricia de A.Petrignet,JulienGouault,NicolasAgustini,TacianeLohézic-Ledévéhat,FrançoiseCariou,AlexandreGrée,RenéEifler-Lima,Vera L.David,Michèleeng2011-10-14T00:00:00Zoai:scielo:S0103-50532009000900018Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-10-14T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
spellingShingle Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
Amaral,Patricia de A.
δ-valerolactones
kavaïn analogues
Heck
Sonogashira-Hagihara
Suzuki-Miyaura
tandem isomerization-aldolization
cytotoxicity
title_short Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title_full Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title_fullStr Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title_full_unstemmed Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title_sort Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
author Amaral,Patricia de A.
author_facet Amaral,Patricia de A.
Petrignet,Julien
Gouault,Nicolas
Agustini,Taciane
Lohézic-Ledévéhat,Françoise
Cariou,Alexandre
Grée,René
Eifler-Lima,Vera L.
David,Michèle
author_role author
author2 Petrignet,Julien
Gouault,Nicolas
Agustini,Taciane
Lohézic-Ledévéhat,Françoise
Cariou,Alexandre
Grée,René
Eifler-Lima,Vera L.
David,Michèle
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Amaral,Patricia de A.
Petrignet,Julien
Gouault,Nicolas
Agustini,Taciane
Lohézic-Ledévéhat,Françoise
Cariou,Alexandre
Grée,René
Eifler-Lima,Vera L.
David,Michèle
dc.subject.por.fl_str_mv δ-valerolactones
kavaïn analogues
Heck
Sonogashira-Hagihara
Suzuki-Miyaura
tandem isomerization-aldolization
cytotoxicity
topic δ-valerolactones
kavaïn analogues
Heck
Sonogashira-Hagihara
Suzuki-Miyaura
tandem isomerization-aldolization
cytotoxicity
description Palladium-catalyzed cross coupling reactions (Sonogashira-Hagihara, Suzuki-Miyaura, and Heck) coupling and nickel hydride-mediated tandem isomerization aldolisation have been used for the synthesis of three series of δ-valerolactones substituted in positions 3, 4, 5 and 6 of the lactone ring. The 26 kavaïn-like derivatives were tested against three cell lines and five of them exhibited a weak cytotoxic activity.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000900018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000900018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532009000900018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.20 n.9 2009
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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