Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)

Detalhes bibliográficos
Autor(a) principal: Bai,Bai
Data de Publicação: 2015
Outros Autores: Gu,Xu-Wei, Chen,Yu, Guan,Fu-Qin, Shan,Yu, Feng,Xu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000400723
Resumo: A new naphthalene, 8-methoxy-2,7-dihydroxyl-4-(1'-hydroxyl-isopropyl)-6-methyl-1-naphthaldehyde, together with twelve known compounds were isolated from the tubers of Kosteletzkya virginica. Their structures were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution time of flight electrospray ionization mass spectrometry (HRTOFESIMS). Some compounds were evaluated for their potential in scavenging diphenyl-picryl hydrazyl radical (DPPH•), inhibition of nitric oxide (NO) induced by lipopolysaccharide (LPS), and cytotoxic activity. The new compound showed activities against DPPH•, NO, human acute promyelocytic leukemia (HL-60) and human colorectal adenocarcinoma (LOVO), with IC50 of 34.6, 12.5, 40.5, 31.7 μmol L-1 respectively.
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spelling Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)naphthaleneKosteletzkya virginicaDPPH•nitric oxidecytotoxic activityA new naphthalene, 8-methoxy-2,7-dihydroxyl-4-(1'-hydroxyl-isopropyl)-6-methyl-1-naphthaldehyde, together with twelve known compounds were isolated from the tubers of Kosteletzkya virginica. Their structures were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution time of flight electrospray ionization mass spectrometry (HRTOFESIMS). Some compounds were evaluated for their potential in scavenging diphenyl-picryl hydrazyl radical (DPPH•), inhibition of nitric oxide (NO) induced by lipopolysaccharide (LPS), and cytotoxic activity. The new compound showed activities against DPPH•, NO, human acute promyelocytic leukemia (HL-60) and human colorectal adenocarcinoma (LOVO), with IC50 of 34.6, 12.5, 40.5, 31.7 μmol L-1 respectively.Sociedade Brasileira de Química2015-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000400723Journal of the Brazilian Chemical Society v.26 n.4 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150032info:eu-repo/semantics/openAccessBai,BaiGu,Xu-WeiChen,YuGuan,Fu-QinShan,YuFeng,Xueng2015-05-11T00:00:00Zoai:scielo:S0103-50532015000400723Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-05-11T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)
title Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)
spellingShingle Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)
Bai,Bai
naphthalene
Kosteletzkya virginica
DPPH•
nitric oxide
cytotoxic activity
title_short Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)
title_full Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)
title_fullStr Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)
title_full_unstemmed Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)
title_sort Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)
author Bai,Bai
author_facet Bai,Bai
Gu,Xu-Wei
Chen,Yu
Guan,Fu-Qin
Shan,Yu
Feng,Xu
author_role author
author2 Gu,Xu-Wei
Chen,Yu
Guan,Fu-Qin
Shan,Yu
Feng,Xu
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bai,Bai
Gu,Xu-Wei
Chen,Yu
Guan,Fu-Qin
Shan,Yu
Feng,Xu
dc.subject.por.fl_str_mv naphthalene
Kosteletzkya virginica
DPPH•
nitric oxide
cytotoxic activity
topic naphthalene
Kosteletzkya virginica
DPPH•
nitric oxide
cytotoxic activity
description A new naphthalene, 8-methoxy-2,7-dihydroxyl-4-(1'-hydroxyl-isopropyl)-6-methyl-1-naphthaldehyde, together with twelve known compounds were isolated from the tubers of Kosteletzkya virginica. Their structures were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution time of flight electrospray ionization mass spectrometry (HRTOFESIMS). Some compounds were evaluated for their potential in scavenging diphenyl-picryl hydrazyl radical (DPPH•), inhibition of nitric oxide (NO) induced by lipopolysaccharide (LPS), and cytotoxic activity. The new compound showed activities against DPPH•, NO, human acute promyelocytic leukemia (HL-60) and human colorectal adenocarcinoma (LOVO), with IC50 of 34.6, 12.5, 40.5, 31.7 μmol L-1 respectively.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000400723
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000400723
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20150032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.26 n.4 2015
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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