Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

• Autor(a) principal: Ávila,Fábio N.
• Data de Publicação: 2017
• Outros Autores: Pinto,Francisco C. L., Sousa,Thiciana S., Torres,Maria Conceição M., Costa-Lotufo,Leticia V., Rocha,Danilo D., Vasconcelos,Mayron A. de, Cardoso-Sá,Nairley, Teixeira,Edson H., Albuquerque,Maria Rose Jane R., Silveira,Edilberto R., Pessoa,Otília D. L.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000601014
• topic: Plectranthus ornatus; diterpenes; ent-clerodanes; bacteriostatic

Five new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of analogous compounds. All isolated compounds were assayed against four human cancer cell lines, and Gram-positive and Gram-negative bacteria strains. None of them showed any cytotoxic activity, but ornatin C, D, E and three related diterpenes displayed marginal bactericidal or bacteriostatic effects against the Gram-positive strains.