An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis

Detalhes bibliográficos
Autor(a) principal: Basso,Luiz A.
Data de Publicação: 2010
Outros Autores: Schneider,Cristopher Z., Santos,Anderson J. A. B. dos, Santos Jr,André A. dos, Campos,Maria M., Souto,André A., Santos,Diógenes S.
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000700026
Resumo: Here we describe the inhibitory activity of IQG607, pentacyano(isoniazid)ferrate(II), on isoniazid-sensitive and isoniazid-resistant strains of Mycobacterium tuberculosis, its oral toxicity, and efforts to adapt IQG607 synthesis to large chemical reactors. IQG607 represents a promising chemotherapeutic agent aiming at the inhibition of a validated and druggable molecular target.
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spelling An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosisMycobacterium tuberculosisenoyl reductasetoxicologylarge-scale synthesismetallodrugHere we describe the inhibitory activity of IQG607, pentacyano(isoniazid)ferrate(II), on isoniazid-sensitive and isoniazid-resistant strains of Mycobacterium tuberculosis, its oral toxicity, and efforts to adapt IQG607 synthesis to large chemical reactors. IQG607 represents a promising chemotherapeutic agent aiming at the inhibition of a validated and druggable molecular target.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000700026Journal of the Brazilian Chemical Society v.21 n.7 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000700026info:eu-repo/semantics/openAccessBasso,Luiz A.Schneider,Cristopher Z.Santos,Anderson J. A. B. dosSantos Jr,André A. dosCampos,Maria M.Souto,André A.Santos,Diógenes S.eng2010-07-30T00:00:00Zoai:scielo:S0103-50532010000700026Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-07-30T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis
title An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis
spellingShingle An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis
Basso,Luiz A.
Mycobacterium tuberculosis
enoyl reductase
toxicology
large-scale synthesis
metallodrug
title_short An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis
title_full An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis
title_fullStr An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis
title_full_unstemmed An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis
title_sort An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis
author Basso,Luiz A.
author_facet Basso,Luiz A.
Schneider,Cristopher Z.
Santos,Anderson J. A. B. dos
Santos Jr,André A. dos
Campos,Maria M.
Souto,André A.
Santos,Diógenes S.
author_role author
author2 Schneider,Cristopher Z.
Santos,Anderson J. A. B. dos
Santos Jr,André A. dos
Campos,Maria M.
Souto,André A.
Santos,Diógenes S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Basso,Luiz A.
Schneider,Cristopher Z.
Santos,Anderson J. A. B. dos
Santos Jr,André A. dos
Campos,Maria M.
Souto,André A.
Santos,Diógenes S.
dc.subject.por.fl_str_mv Mycobacterium tuberculosis
enoyl reductase
toxicology
large-scale synthesis
metallodrug
topic Mycobacterium tuberculosis
enoyl reductase
toxicology
large-scale synthesis
metallodrug
description Here we describe the inhibitory activity of IQG607, pentacyano(isoniazid)ferrate(II), on isoniazid-sensitive and isoniazid-resistant strains of Mycobacterium tuberculosis, its oral toxicity, and efforts to adapt IQG607 synthesis to large chemical reactors. IQG607 represents a promising chemotherapeutic agent aiming at the inhibition of a validated and druggable molecular target.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000700026
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000700026
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010000700026
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.7 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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