Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry

Detalhes bibliográficos
Autor(a) principal: Brito,Talita P. de
Data de Publicação: 2021
Outros Autores: Aguiar,Deborah V. A. de, Pereira,Igor, Vaz,Boniek G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000200269
Resumo: The usefulness of molecularly imprinted polymer assisted paper spray ionization mass spectrometry (MIP-PSI-MS) for the determination of methamphetamine in urine has been demonstrated. MIP-PSI-MS is a method in which a MIP is synthesized on the surface of a paper, producing a chemically selective paper surface with molecular recognition sites for a target analyte. The analyte is extracted by the MIP substrate, which is posteriorly used for conventional PSI-MS analysis. As methamphetamine is one of the most widely used drugs of abuse in the world, it was selected to be studied in synthetic urine by the MIP-PSI-MS method. Methamphetamine was detected at higher ion signals compared to other different drugs, such as lysergic acid diethylamide (LSD) and cocaine, suggesting that MIP-PSI-MS has a chemical affinity for methamphetamine. In experiments to validate the method, a linear calibration curve was achieved with R-squared (R2) > 0.99. Limit of detection (LOD) and limit of quantification (LOQ) were determined to be 0.8 and 2.8 µg L-1, respectively. Precision (relative standard deviation) and accuracy (relative error) were less than 10%, and the recoveries were close to 100%. The matrix effect was below 10%. These data demonstrate the possibility of using MIP-PSI-MS as an analytical tool for a specific/selective analysis of methamphetamine in forensic sciences.
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spelling Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometryambient mass spectrometrypaper spray ionizationmolecularly imprinted polymermethamphetamineThe usefulness of molecularly imprinted polymer assisted paper spray ionization mass spectrometry (MIP-PSI-MS) for the determination of methamphetamine in urine has been demonstrated. MIP-PSI-MS is a method in which a MIP is synthesized on the surface of a paper, producing a chemically selective paper surface with molecular recognition sites for a target analyte. The analyte is extracted by the MIP substrate, which is posteriorly used for conventional PSI-MS analysis. As methamphetamine is one of the most widely used drugs of abuse in the world, it was selected to be studied in synthetic urine by the MIP-PSI-MS method. Methamphetamine was detected at higher ion signals compared to other different drugs, such as lysergic acid diethylamide (LSD) and cocaine, suggesting that MIP-PSI-MS has a chemical affinity for methamphetamine. In experiments to validate the method, a linear calibration curve was achieved with R-squared (R2) > 0.99. Limit of detection (LOD) and limit of quantification (LOQ) were determined to be 0.8 and 2.8 µg L-1, respectively. Precision (relative standard deviation) and accuracy (relative error) were less than 10%, and the recoveries were close to 100%. The matrix effect was below 10%. These data demonstrate the possibility of using MIP-PSI-MS as an analytical tool for a specific/selective analysis of methamphetamine in forensic sciences.Sociedade Brasileira de Química2021-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000200269Journal of the Brazilian Chemical Society v.32 n.2 2021reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20200177info:eu-repo/semantics/openAccessBrito,Talita P. deAguiar,Deborah V. A. dePereira,IgorVaz,Boniek G.eng2021-01-28T00:00:00Zoai:scielo:S0103-50532021000200269Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2021-01-28T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry
title Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry
spellingShingle Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry
Brito,Talita P. de
ambient mass spectrometry
paper spray ionization
molecularly imprinted polymer
methamphetamine
title_short Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry
title_full Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry
title_fullStr Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry
title_full_unstemmed Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry
title_sort Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry
author Brito,Talita P. de
author_facet Brito,Talita P. de
Aguiar,Deborah V. A. de
Pereira,Igor
Vaz,Boniek G.
author_role author
author2 Aguiar,Deborah V. A. de
Pereira,Igor
Vaz,Boniek G.
author2_role author
author
author
dc.contributor.author.fl_str_mv Brito,Talita P. de
Aguiar,Deborah V. A. de
Pereira,Igor
Vaz,Boniek G.
dc.subject.por.fl_str_mv ambient mass spectrometry
paper spray ionization
molecularly imprinted polymer
methamphetamine
topic ambient mass spectrometry
paper spray ionization
molecularly imprinted polymer
methamphetamine
description The usefulness of molecularly imprinted polymer assisted paper spray ionization mass spectrometry (MIP-PSI-MS) for the determination of methamphetamine in urine has been demonstrated. MIP-PSI-MS is a method in which a MIP is synthesized on the surface of a paper, producing a chemically selective paper surface with molecular recognition sites for a target analyte. The analyte is extracted by the MIP substrate, which is posteriorly used for conventional PSI-MS analysis. As methamphetamine is one of the most widely used drugs of abuse in the world, it was selected to be studied in synthetic urine by the MIP-PSI-MS method. Methamphetamine was detected at higher ion signals compared to other different drugs, such as lysergic acid diethylamide (LSD) and cocaine, suggesting that MIP-PSI-MS has a chemical affinity for methamphetamine. In experiments to validate the method, a linear calibration curve was achieved with R-squared (R2) > 0.99. Limit of detection (LOD) and limit of quantification (LOQ) were determined to be 0.8 and 2.8 µg L-1, respectively. Precision (relative standard deviation) and accuracy (relative error) were less than 10%, and the recoveries were close to 100%. The matrix effect was below 10%. These data demonstrate the possibility of using MIP-PSI-MS as an analytical tool for a specific/selective analysis of methamphetamine in forensic sciences.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000200269
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000200269
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0103-5053.20200177
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.32 n.2 2021
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
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reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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