Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100054 |
Resumo: | A glassy carbon electrode modified with a molecularly imprinted polymer (MIP) containing phenacetin recognition sites is introduced. The phenacetin-selective MIP was synthesised based on the electropolymerisation of pyrrole in a 1:1 (v/v) water/ethanol with HClO4 solution. The MIP-modified electrode showed higher recognition ability in comparison with a bare electrode for procaine and aminopyrine, reported to electrochemically interfere in the quantification of phenacetin in cocaine samples. In addition, the MIP was able to preconcentrate one of the intermediates of the phenacetin electrochemical oxidation, acetaminophen, indicating the possibility of monitoring phenacetin based on the acetaminophen oxidation. The acetaminophen oxidation peak is 15 times more detectable compared to the signal obtained by the non-molecularly imprinted polymer (NIP), and it occurs 450 mV below the phenacetin electrochemical oxidation signal. These achieved characteristics decrease the possibility of interference from other electrochemical reactions that may occur in the same potential range as phenacetin electrochemical process. |
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Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophenelectrochemical sensormolecularly imprinted polymercocaine samplesparacetamolforensic applicationA glassy carbon electrode modified with a molecularly imprinted polymer (MIP) containing phenacetin recognition sites is introduced. The phenacetin-selective MIP was synthesised based on the electropolymerisation of pyrrole in a 1:1 (v/v) water/ethanol with HClO4 solution. The MIP-modified electrode showed higher recognition ability in comparison with a bare electrode for procaine and aminopyrine, reported to electrochemically interfere in the quantification of phenacetin in cocaine samples. In addition, the MIP was able to preconcentrate one of the intermediates of the phenacetin electrochemical oxidation, acetaminophen, indicating the possibility of monitoring phenacetin based on the acetaminophen oxidation. The acetaminophen oxidation peak is 15 times more detectable compared to the signal obtained by the non-molecularly imprinted polymer (NIP), and it occurs 450 mV below the phenacetin electrochemical oxidation signal. These achieved characteristics decrease the possibility of interference from other electrochemical reactions that may occur in the same potential range as phenacetin electrochemical process.Sociedade Brasileira de Química2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100054Journal of the Brazilian Chemical Society v.27 n.1 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150240info:eu-repo/semantics/openAccessSalles,Maiara O.Araujo,William R.Paixão,Thiago R. L. C.eng2016-03-09T00:00:00Zoai:scielo:S0103-50532016000100054Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-03-09T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen |
title |
Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen |
spellingShingle |
Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen Salles,Maiara O. electrochemical sensor molecularly imprinted polymer cocaine samples paracetamol forensic application |
title_short |
Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen |
title_full |
Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen |
title_fullStr |
Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen |
title_full_unstemmed |
Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen |
title_sort |
Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen |
author |
Salles,Maiara O. |
author_facet |
Salles,Maiara O. Araujo,William R. Paixão,Thiago R. L. C. |
author_role |
author |
author2 |
Araujo,William R. Paixão,Thiago R. L. C. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Salles,Maiara O. Araujo,William R. Paixão,Thiago R. L. C. |
dc.subject.por.fl_str_mv |
electrochemical sensor molecularly imprinted polymer cocaine samples paracetamol forensic application |
topic |
electrochemical sensor molecularly imprinted polymer cocaine samples paracetamol forensic application |
description |
A glassy carbon electrode modified with a molecularly imprinted polymer (MIP) containing phenacetin recognition sites is introduced. The phenacetin-selective MIP was synthesised based on the electropolymerisation of pyrrole in a 1:1 (v/v) water/ethanol with HClO4 solution. The MIP-modified electrode showed higher recognition ability in comparison with a bare electrode for procaine and aminopyrine, reported to electrochemically interfere in the quantification of phenacetin in cocaine samples. In addition, the MIP was able to preconcentrate one of the intermediates of the phenacetin electrochemical oxidation, acetaminophen, indicating the possibility of monitoring phenacetin based on the acetaminophen oxidation. The acetaminophen oxidation peak is 15 times more detectable compared to the signal obtained by the non-molecularly imprinted polymer (NIP), and it occurs 450 mV below the phenacetin electrochemical oxidation signal. These achieved characteristics decrease the possibility of interference from other electrochemical reactions that may occur in the same potential range as phenacetin electrochemical process. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100054 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100054 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20150240 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.27 n.1 2016 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318177895579648 |