Synthesis and structural confirmation of natural 1,3-diarylpropanes

• Autor(a) principal: Almeida,Paulo A. de
• Data de Publicação: 1999
• Outros Autores: Fraiz Jr.,Silas V., Braz-Filho,Raimundo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000500002
• topic: Iryanthera laevis; 1,3-Diarylpropanes; reduction of chalcones

1-(4’-Hydroxy-5’-methyl-2’-methoxyphenyl)-3-(2"-hydroxy-4",5"-methylenedioxyphenyl) propane (7), 1,3-diarylpropane isolated from Iryanthera laevis, 1-(4’-hydroxy-2’-methoxyphenyl)-3-(4"-hydroxyphenyl)propane (2, broussonin B) and 1-(2’-hydroxy-4’-methoxyphenyl)-3-(4"-hydroxyphenyl)propane (1, broussonin A), isolated from Broussonetia papyrifera Vent. (Moraceae), and 1-(2’,4’-dimethoxyphenyl)-3-(4"-hydroxyphenyl)propane, a synthetic product prepared by catalytic hydrogenation of 4-O-benzyl-2’,4’-dimethoxychalcone, were synthesized. The synthetic pathway employed in this work involved the catalytic hydrogenation of chalcones obtained by base condensation of acetophenones and benzaldehydes.