Clinical applications and methemoglobinemia induced by dapsone

Detalhes bibliográficos
Autor(a) principal: Oliveira,Fábio R.
Data de Publicação: 2014
Outros Autores: Pessoa,Mariely C., Albuquerque,Rosyana F. V., Schalcher,Taysa R., Monteiro,Marta C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000003
Resumo: Dapsone is a synthetic sulfone that is used as an antibiotic in humans and animals to prevent and treat diseases including leprosy, tuberculosis, malaria, and Pneumocystis carinii pneumonia and Toxoplasma gondii encephalitis in acquired immune deficiency syndrome (AIDS) patients as well as in anti-inflammatory conditions, such as dermatitis herpetiformis. However, this drug is also associated with several adverse effects, including dose-related hemolysis, methemoglobinemia, psychosis, peripheral neuropathy, agranulocytosis, aplastic anemia, hypersensitivity syndrome, sulfone syndrome, and others. Of these effects, methemoglobinemia is the most common side effect of dapsone, which leads to functional anemia and cellular hypoxia with symptoms of cyanosis, headache, fatigue, tachycardia, weakness, and dizziness. Thus, this review summarizes relevant information on the structure, mechanism of action, clinical indication, and adverse reactions of dapsone.
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spelling Clinical applications and methemoglobinemia induced by dapsonedapsonemethemoglobinemia4,4'-diamino-diphenylsulfonedapsone hydroxylamineDapsone is a synthetic sulfone that is used as an antibiotic in humans and animals to prevent and treat diseases including leprosy, tuberculosis, malaria, and Pneumocystis carinii pneumonia and Toxoplasma gondii encephalitis in acquired immune deficiency syndrome (AIDS) patients as well as in anti-inflammatory conditions, such as dermatitis herpetiformis. However, this drug is also associated with several adverse effects, including dose-related hemolysis, methemoglobinemia, psychosis, peripheral neuropathy, agranulocytosis, aplastic anemia, hypersensitivity syndrome, sulfone syndrome, and others. Of these effects, methemoglobinemia is the most common side effect of dapsone, which leads to functional anemia and cellular hypoxia with symptoms of cyanosis, headache, fatigue, tachycardia, weakness, and dizziness. Thus, this review summarizes relevant information on the structure, mechanism of action, clinical indication, and adverse reactions of dapsone.Sociedade Brasileira de Química2014-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000003Journal of the Brazilian Chemical Society v.25 n.10 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140168info:eu-repo/semantics/openAccessOliveira,Fábio R.Pessoa,Mariely C.Albuquerque,Rosyana F. V.Schalcher,Taysa R.Monteiro,Marta C.eng2014-10-27T00:00:00Zoai:scielo:S0103-50532014001000003Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-10-27T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Clinical applications and methemoglobinemia induced by dapsone
title Clinical applications and methemoglobinemia induced by dapsone
spellingShingle Clinical applications and methemoglobinemia induced by dapsone
Oliveira,Fábio R.
dapsone
methemoglobinemia
4,4'-diamino-diphenylsulfone
dapsone hydroxylamine
title_short Clinical applications and methemoglobinemia induced by dapsone
title_full Clinical applications and methemoglobinemia induced by dapsone
title_fullStr Clinical applications and methemoglobinemia induced by dapsone
title_full_unstemmed Clinical applications and methemoglobinemia induced by dapsone
title_sort Clinical applications and methemoglobinemia induced by dapsone
author Oliveira,Fábio R.
author_facet Oliveira,Fábio R.
Pessoa,Mariely C.
Albuquerque,Rosyana F. V.
Schalcher,Taysa R.
Monteiro,Marta C.
author_role author
author2 Pessoa,Mariely C.
Albuquerque,Rosyana F. V.
Schalcher,Taysa R.
Monteiro,Marta C.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Fábio R.
Pessoa,Mariely C.
Albuquerque,Rosyana F. V.
Schalcher,Taysa R.
Monteiro,Marta C.
dc.subject.por.fl_str_mv dapsone
methemoglobinemia
4,4'-diamino-diphenylsulfone
dapsone hydroxylamine
topic dapsone
methemoglobinemia
4,4'-diamino-diphenylsulfone
dapsone hydroxylamine
description Dapsone is a synthetic sulfone that is used as an antibiotic in humans and animals to prevent and treat diseases including leprosy, tuberculosis, malaria, and Pneumocystis carinii pneumonia and Toxoplasma gondii encephalitis in acquired immune deficiency syndrome (AIDS) patients as well as in anti-inflammatory conditions, such as dermatitis herpetiformis. However, this drug is also associated with several adverse effects, including dose-related hemolysis, methemoglobinemia, psychosis, peripheral neuropathy, agranulocytosis, aplastic anemia, hypersensitivity syndrome, sulfone syndrome, and others. Of these effects, methemoglobinemia is the most common side effect of dapsone, which leads to functional anemia and cellular hypoxia with symptoms of cyanosis, headache, fatigue, tachycardia, weakness, and dizziness. Thus, this review summarizes relevant information on the structure, mechanism of action, clinical indication, and adverse reactions of dapsone.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20140168
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.25 n.10 2014
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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