Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus

• Autor(a) principal: Siani,Antonio C.
• Data de Publicação: 2001
• Outros Autores: Silva,Ana M. P., Nakamura,Marcos J., De Carvalho,Márcia V., Henriques,Maria G. M. O., Ramos,Mônica F. S., Kaiser,Carlos R.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300006
• topic: Mariscus pedunculatus; benzofuran derivative; remirol; iso-evodionol; anti-inflammatory activity

A mixture of the benzofuran remirol and the benzopyran isoevodionol (5.7:1) was extracted by hydrodistillation from rhizomes of Mariscus pedunculatus. They were purified by successive thin layer chromatography. Their structure elucidation were confirmed by 2D-NMR experiments. The structure of remirol was also confirmed by its hydrogenation product. Crude distillate and the pure compounds were screened for anti-inflammatory activity by the use of the mouse pleurisy model induced by lipopolysaccharide (LPS, 12.5 ng/cavity). Both the mixture and remirol showed a dose-dependent (100 and 200 mg kg-1 p. o.) capacity to inhibit neutrophil and eosinophil accumulation in the mouse pleural cavity. In contrast, no anti-inflammatory effect was observed for iso-evodionol.