LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation

Detalhes bibliográficos
Autor(a) principal: Maurin,Andrea J. M.
Data de Publicação: 2003
Outros Autores: Iamamoto,Yassuko, Lopes,Norberto P., Lindsay-Smith,John R., Bonato,Pierina S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000200022
Resumo: In this paper we report the application of liquid chromatography-mass spectrometry (LC-MS-MS) to the identification of the products formed by oxidation of albendazole and disopyramide with metalloporphyrins in dichloroethane, using iodosylbenzene as an oxygen donor. Our results show that LC-MS-MS is a powerful tool to study the in vitro metabolism of drugs, allowing the identification of known and unknown metabolites. In addition, it was observed that the catalyst system used resulted in the formation of the same metabolites as obtained in vivo, although for disopyramide other products were also observed.
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spelling LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidationLC-MS-MSmetabolismmetalloporphyrindisopyramidealbendazoleIn this paper we report the application of liquid chromatography-mass spectrometry (LC-MS-MS) to the identification of the products formed by oxidation of albendazole and disopyramide with metalloporphyrins in dichloroethane, using iodosylbenzene as an oxygen donor. Our results show that LC-MS-MS is a powerful tool to study the in vitro metabolism of drugs, allowing the identification of known and unknown metabolites. In addition, it was observed that the catalyst system used resulted in the formation of the same metabolites as obtained in vivo, although for disopyramide other products were also observed.Sociedade Brasileira de Química2003-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000200022Journal of the Brazilian Chemical Society v.14 n.2 2003reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532003000200022info:eu-repo/semantics/openAccessMaurin,Andrea J. M.Iamamoto,YassukoLopes,Norberto P.Lindsay-Smith,John R.Bonato,Pierina S.eng2015-11-26T00:00:00Zoai:scielo:S0103-50532003000200022Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-11-26T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation
title LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation
spellingShingle LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation
Maurin,Andrea J. M.
LC-MS-MS
metabolism
metalloporphyrin
disopyramide
albendazole
title_short LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation
title_full LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation
title_fullStr LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation
title_full_unstemmed LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation
title_sort LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation
author Maurin,Andrea J. M.
author_facet Maurin,Andrea J. M.
Iamamoto,Yassuko
Lopes,Norberto P.
Lindsay-Smith,John R.
Bonato,Pierina S.
author_role author
author2 Iamamoto,Yassuko
Lopes,Norberto P.
Lindsay-Smith,John R.
Bonato,Pierina S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Maurin,Andrea J. M.
Iamamoto,Yassuko
Lopes,Norberto P.
Lindsay-Smith,John R.
Bonato,Pierina S.
dc.subject.por.fl_str_mv LC-MS-MS
metabolism
metalloporphyrin
disopyramide
albendazole
topic LC-MS-MS
metabolism
metalloporphyrin
disopyramide
albendazole
description In this paper we report the application of liquid chromatography-mass spectrometry (LC-MS-MS) to the identification of the products formed by oxidation of albendazole and disopyramide with metalloporphyrins in dichloroethane, using iodosylbenzene as an oxygen donor. Our results show that LC-MS-MS is a powerful tool to study the in vitro metabolism of drugs, allowing the identification of known and unknown metabolites. In addition, it was observed that the catalyst system used resulted in the formation of the same metabolites as obtained in vivo, although for disopyramide other products were also observed.
publishDate 2003
dc.date.none.fl_str_mv 2003-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000200022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000200022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532003000200022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.14 n.2 2003
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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