Synthesis of novel quinolines using TsOH/ionic liquid under microwave

• Autor(a) principal: Prola,Liziê D. T.
• Data de Publicação: 2012
• Outros Autores: Buriol,Lilian, Frizzo,Clarissa P., Caleffi,Guilherme S., Marzari,Mara R. B., Moreira,Dayse N., Bonacorso,Helio G., Zanatta,Nilo, Martins,Marcos A. P.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000900011
• topic: ionic liquid; quinoline; toluene sulfonic acid; microwave-assisted synthesis (MW); enones

In this work, 3-haloacetyl-4-methylquinolines were synthesized from the reaction of 4-alkoxy-3-alken-2-ones [R¹C(O)CH=C(R²)OCH3, where R¹ = CF3, CCl3, CHCl2, CF2Cl, CF2CF3 and R² = Me, Et, Pr, Bu, i-Bu and i-Pe] and 2-aminoacetophenone. The reaction was performed in ionic liquid and 4-toluene sulfonic acid under microwave irradiation. Results showed that the catalytic method was effective. Products were formed in a short time (10-20 min) and presented good yields (70-91%).