Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000901959 |
Resumo: | This paper presents a simple and low-cost capillary electrophoresis method for ultra-fast simultaneous determination of naphazoline (NPZ) and one of the following active ingredients: diphenhydramine (DIP), pheniramine (PHEN) or chlorpheniramine (CPHEN). The proposed method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) equipped with a short length capillary column (10 cm). One sample can be analyzed every 35 s (ca. 100 injections per hour) with resolutions between peaks greater than 1.4. The optimized background electrolyte (BGE) was composed by 20 mmol L-1 histidine and 10 mmol L-1 3,4-dimethoxycinnamic acid (pH = 9.5, adjusted with NaOH). Limits of detection were 25 µmol L-1 for NPZ, DIP, and PHEN and 13 µmol L-1 for CPHEN. The results obtained with the developed procedure were compared to those obtained by high-performance liquid chromatography (HPLC) and no statistically significant differences were observed (95% confidence level). |
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Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresisshort length columnsub-minute separationquality controlantihistaminesimidazole derivativeThis paper presents a simple and low-cost capillary electrophoresis method for ultra-fast simultaneous determination of naphazoline (NPZ) and one of the following active ingredients: diphenhydramine (DIP), pheniramine (PHEN) or chlorpheniramine (CPHEN). The proposed method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) equipped with a short length capillary column (10 cm). One sample can be analyzed every 35 s (ca. 100 injections per hour) with resolutions between peaks greater than 1.4. The optimized background electrolyte (BGE) was composed by 20 mmol L-1 histidine and 10 mmol L-1 3,4-dimethoxycinnamic acid (pH = 9.5, adjusted with NaOH). Limits of detection were 25 µmol L-1 for NPZ, DIP, and PHEN and 13 µmol L-1 for CPHEN. The results obtained with the developed procedure were compared to those obtained by high-performance liquid chromatography (HPLC) and no statistically significant differences were observed (95% confidence level).Sociedade Brasileira de Química2018-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000901959Journal of the Brazilian Chemical Society v.29 n.9 2018reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20180073info:eu-repo/semantics/openAccessRibeiro,Michelle M. A. C.Marra,Mariana C.Costa,Brenda M. C.Oliveira,Thiago C.Batista,Alex D.Muñoz,Rodrigo A. A.Richter,Eduardo M.eng2018-08-16T00:00:00Zoai:scielo:S0103-50532018000901959Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2018-08-16T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresis |
title |
Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresis |
spellingShingle |
Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresis Ribeiro,Michelle M. A. C. short length column sub-minute separation quality control antihistamines imidazole derivative |
title_short |
Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresis |
title_full |
Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresis |
title_fullStr |
Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresis |
title_full_unstemmed |
Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresis |
title_sort |
Sub-Minute Method for Determination of Naphazoline in the Presence of Diphenhydramine, Pheniramine or Chlorpheniramine by Capillary Electrophoresis |
author |
Ribeiro,Michelle M. A. C. |
author_facet |
Ribeiro,Michelle M. A. C. Marra,Mariana C. Costa,Brenda M. C. Oliveira,Thiago C. Batista,Alex D. Muñoz,Rodrigo A. A. Richter,Eduardo M. |
author_role |
author |
author2 |
Marra,Mariana C. Costa,Brenda M. C. Oliveira,Thiago C. Batista,Alex D. Muñoz,Rodrigo A. A. Richter,Eduardo M. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Ribeiro,Michelle M. A. C. Marra,Mariana C. Costa,Brenda M. C. Oliveira,Thiago C. Batista,Alex D. Muñoz,Rodrigo A. A. Richter,Eduardo M. |
dc.subject.por.fl_str_mv |
short length column sub-minute separation quality control antihistamines imidazole derivative |
topic |
short length column sub-minute separation quality control antihistamines imidazole derivative |
description |
This paper presents a simple and low-cost capillary electrophoresis method for ultra-fast simultaneous determination of naphazoline (NPZ) and one of the following active ingredients: diphenhydramine (DIP), pheniramine (PHEN) or chlorpheniramine (CPHEN). The proposed method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) equipped with a short length capillary column (10 cm). One sample can be analyzed every 35 s (ca. 100 injections per hour) with resolutions between peaks greater than 1.4. The optimized background electrolyte (BGE) was composed by 20 mmol L-1 histidine and 10 mmol L-1 3,4-dimethoxycinnamic acid (pH = 9.5, adjusted with NaOH). Limits of detection were 25 µmol L-1 for NPZ, DIP, and PHEN and 13 µmol L-1 for CPHEN. The results obtained with the developed procedure were compared to those obtained by high-performance liquid chromatography (HPLC) and no statistically significant differences were observed (95% confidence level). |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000901959 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000901959 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20180073 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.29 n.9 2018 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318181194399744 |