A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine

Detalhes bibliográficos
Autor(a) principal: Bao,Xue-fei
Data de Publicação: 2016
Outros Autores: Qiao,Xue-jun, Hou,Xiao, Fang,Wu-hong, Liu,Xue-long, Chen,Guo-liang
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001202388
Resumo: 5-(Trifluoromethyl)-2-thiazolamine is a key intermediate for manufacturing numerous pharmaceuticals and chemicals. Here, a low-cost, one-pot multicomponent domino synthetic route has been reported for the synthesis of 5-(trifluoromethyl)-2-thiazolamine, which was successfully prepared from 3-bromo-1,1,1-trifluoro-2-propanone, phosphorus pentasulfide and cyanamide in the presence of sodium carbonate with the yield of 56%.
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spelling A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine5-(trifluoromethyl)-2-thiazolamineone-potdomino synthesisnitrogen heterocycle5-(Trifluoromethyl)-2-thiazolamine is a key intermediate for manufacturing numerous pharmaceuticals and chemicals. Here, a low-cost, one-pot multicomponent domino synthetic route has been reported for the synthesis of 5-(trifluoromethyl)-2-thiazolamine, which was successfully prepared from 3-bromo-1,1,1-trifluoro-2-propanone, phosphorus pentasulfide and cyanamide in the presence of sodium carbonate with the yield of 56%.Sociedade Brasileira de Química2016-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001202388Journal of the Brazilian Chemical Society v.27 n.12 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20160132info:eu-repo/semantics/openAccessBao,Xue-feiQiao,Xue-junHou,XiaoFang,Wu-hongLiu,Xue-longChen,Guo-liangeng2016-12-01T00:00:00Zoai:scielo:S0103-50532016001202388Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-12-01T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine
title A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine
spellingShingle A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine
Bao,Xue-fei
5-(trifluoromethyl)-2-thiazolamine
one-pot
domino synthesis
nitrogen heterocycle
title_short A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine
title_full A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine
title_fullStr A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine
title_full_unstemmed A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine
title_sort A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine
author Bao,Xue-fei
author_facet Bao,Xue-fei
Qiao,Xue-jun
Hou,Xiao
Fang,Wu-hong
Liu,Xue-long
Chen,Guo-liang
author_role author
author2 Qiao,Xue-jun
Hou,Xiao
Fang,Wu-hong
Liu,Xue-long
Chen,Guo-liang
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bao,Xue-fei
Qiao,Xue-jun
Hou,Xiao
Fang,Wu-hong
Liu,Xue-long
Chen,Guo-liang
dc.subject.por.fl_str_mv 5-(trifluoromethyl)-2-thiazolamine
one-pot
domino synthesis
nitrogen heterocycle
topic 5-(trifluoromethyl)-2-thiazolamine
one-pot
domino synthesis
nitrogen heterocycle
description 5-(Trifluoromethyl)-2-thiazolamine is a key intermediate for manufacturing numerous pharmaceuticals and chemicals. Here, a low-cost, one-pot multicomponent domino synthetic route has been reported for the synthesis of 5-(trifluoromethyl)-2-thiazolamine, which was successfully prepared from 3-bromo-1,1,1-trifluoro-2-propanone, phosphorus pentasulfide and cyanamide in the presence of sodium carbonate with the yield of 56%.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001202388
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016001202388
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20160132
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.27 n.12 2016
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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