Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticals
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100153 |
Resumo: | This paper presents an analytical procedure for the determination of folic acid employing commutation flow analysis process and detection by chemiluminescence. The procedure is based on the reaction of hexacyanoferrate(III) with folic acid, followed of luminol oxidizing reaction in alkaline medium, resulting in emission of radiation at 425 nm. After optimization the experimental variables, the proposed procedure afforded the following useful features. A linear response ranging from 0.1 to 1.00 mg mL-1 folic acid (R2= 0.993), a detection limit (3σ criterion) 0.046 mg mL-1, a sampling rate of 156 determination per hour, a relative standard deviation less than 0.5% (n = 6) for a 0.6 mg mL->1 folic acid standard solution and a waste generation of 0.86 mL per determination. |
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Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticalsfolic acidmulticommuted flow analysischemiluminescencegreen chemistryThis paper presents an analytical procedure for the determination of folic acid employing commutation flow analysis process and detection by chemiluminescence. The procedure is based on the reaction of hexacyanoferrate(III) with folic acid, followed of luminol oxidizing reaction in alkaline medium, resulting in emission of radiation at 425 nm. After optimization the experimental variables, the proposed procedure afforded the following useful features. A linear response ranging from 0.1 to 1.00 mg mL-1 folic acid (R2= 0.993), a detection limit (3σ criterion) 0.046 mg mL-1, a sampling rate of 156 determination per hour, a relative standard deviation less than 0.5% (n = 6) for a 0.6 mg mL->1 folic acid standard solution and a waste generation of 0.86 mL per determination.Sociedade Brasileira de Química2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100153Journal of the Brazilian Chemical Society v.27 n.1 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150265info:eu-repo/semantics/openAccessLima,Manoel J. A.Vieira,Gláucia P.Fernandes,Ridvan N.Tanaka,Auro A.Reis,Boaventura F.eng2016-03-09T00:00:00Zoai:scielo:S0103-50532016000100153Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-03-09T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticals |
title |
Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticals |
spellingShingle |
Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticals Lima,Manoel J. A. folic acid multicommuted flow analysis chemiluminescence green chemistry |
title_short |
Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticals |
title_full |
Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticals |
title_fullStr |
Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticals |
title_full_unstemmed |
Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticals |
title_sort |
Development of a Procedure Based on Chemiluminescence and Multicommutation Approach for the Determination of Folic Acid in Pharmaceuticals |
author |
Lima,Manoel J. A. |
author_facet |
Lima,Manoel J. A. Vieira,Gláucia P. Fernandes,Ridvan N. Tanaka,Auro A. Reis,Boaventura F. |
author_role |
author |
author2 |
Vieira,Gláucia P. Fernandes,Ridvan N. Tanaka,Auro A. Reis,Boaventura F. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lima,Manoel J. A. Vieira,Gláucia P. Fernandes,Ridvan N. Tanaka,Auro A. Reis,Boaventura F. |
dc.subject.por.fl_str_mv |
folic acid multicommuted flow analysis chemiluminescence green chemistry |
topic |
folic acid multicommuted flow analysis chemiluminescence green chemistry |
description |
This paper presents an analytical procedure for the determination of folic acid employing commutation flow analysis process and detection by chemiluminescence. The procedure is based on the reaction of hexacyanoferrate(III) with folic acid, followed of luminol oxidizing reaction in alkaline medium, resulting in emission of radiation at 425 nm. After optimization the experimental variables, the proposed procedure afforded the following useful features. A linear response ranging from 0.1 to 1.00 mg mL-1 folic acid (R2= 0.993), a detection limit (3σ criterion) 0.046 mg mL-1, a sampling rate of 156 determination per hour, a relative standard deviation less than 0.5% (n = 6) for a 0.6 mg mL->1 folic acid standard solution and a waste generation of 0.86 mL per determination. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100153 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100153 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20150265 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.27 n.1 2016 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318177914454016 |