Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.

Detalhes bibliográficos
Autor(a) principal: Carvalho,Kaline R.
Data de Publicação: 2015
Outros Autores: Silva,Alison B., Torres,Maria Conceição M., Pinto,Francisco Chagas L., Guimarães,Larissa A., Rocha,Danilo D., Silveira,Edilberto R., Costa-Lotufo,Letícia V., Braz‑Filho,Raimundo, Pessoa,Otília Deusdênia. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001001976
Resumo: One new alkaloid, 2α-10bα-dihydroxy-9-O-demethylhomolycorine, in addition to seven others known alkaloids, and 5-(hydroxymethyl)furfural, piscidic acid and eucomic acid, were isolated from the bulbs of Hippeastrum solandriflorum. The structures of all compounds were determined using nuclear magnetic resonance (NMR) spectroscopic techniques: 1H NMR and 13C NMR, heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), nuclear Overhauser effect spectroscopy (NOESY), and also the high-resolution electrospray ionization mass spectrometry (EI-HRMS). The cytotoxic activity of all alkaloids was evaluated against three human cancer cell lines (HCT-116, HL-60, OVCAR8 and SF-295) showing IC50 values ranging from 0.01 to 35.7 µM.
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spelling Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.Hippeastrum solandriflorumAmaryllidaceae alkaloidscytotoxic activityOne new alkaloid, 2α-10bα-dihydroxy-9-O-demethylhomolycorine, in addition to seven others known alkaloids, and 5-(hydroxymethyl)furfural, piscidic acid and eucomic acid, were isolated from the bulbs of Hippeastrum solandriflorum. The structures of all compounds were determined using nuclear magnetic resonance (NMR) spectroscopic techniques: 1H NMR and 13C NMR, heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), nuclear Overhauser effect spectroscopy (NOESY), and also the high-resolution electrospray ionization mass spectrometry (EI-HRMS). The cytotoxic activity of all alkaloids was evaluated against three human cancer cell lines (HCT-116, HL-60, OVCAR8 and SF-295) showing IC50 values ranging from 0.01 to 35.7 µM.Sociedade Brasileira de Química2015-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001001976Journal of the Brazilian Chemical Society v.26 n.10 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150176info:eu-repo/semantics/openAccessCarvalho,Kaline R.Silva,Alison B.Torres,Maria Conceição M.Pinto,Francisco Chagas L.Guimarães,Larissa A.Rocha,Danilo D.Silveira,Edilberto R.Costa-Lotufo,Letícia V.Braz‑Filho,RaimundoPessoa,Otília Deusdênia. L.eng2015-10-22T00:00:00Zoai:scielo:S0103-50532015001001976Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-10-22T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
title Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
spellingShingle Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
Carvalho,Kaline R.
Hippeastrum solandriflorum
Amaryllidaceae alkaloids
cytotoxic activity
title_short Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
title_full Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
title_fullStr Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
title_full_unstemmed Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
title_sort Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
author Carvalho,Kaline R.
author_facet Carvalho,Kaline R.
Silva,Alison B.
Torres,Maria Conceição M.
Pinto,Francisco Chagas L.
Guimarães,Larissa A.
Rocha,Danilo D.
Silveira,Edilberto R.
Costa-Lotufo,Letícia V.
Braz‑Filho,Raimundo
Pessoa,Otília Deusdênia. L.
author_role author
author2 Silva,Alison B.
Torres,Maria Conceição M.
Pinto,Francisco Chagas L.
Guimarães,Larissa A.
Rocha,Danilo D.
Silveira,Edilberto R.
Costa-Lotufo,Letícia V.
Braz‑Filho,Raimundo
Pessoa,Otília Deusdênia. L.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho,Kaline R.
Silva,Alison B.
Torres,Maria Conceição M.
Pinto,Francisco Chagas L.
Guimarães,Larissa A.
Rocha,Danilo D.
Silveira,Edilberto R.
Costa-Lotufo,Letícia V.
Braz‑Filho,Raimundo
Pessoa,Otília Deusdênia. L.
dc.subject.por.fl_str_mv Hippeastrum solandriflorum
Amaryllidaceae alkaloids
cytotoxic activity
topic Hippeastrum solandriflorum
Amaryllidaceae alkaloids
cytotoxic activity
description One new alkaloid, 2α-10bα-dihydroxy-9-O-demethylhomolycorine, in addition to seven others known alkaloids, and 5-(hydroxymethyl)furfural, piscidic acid and eucomic acid, were isolated from the bulbs of Hippeastrum solandriflorum. The structures of all compounds were determined using nuclear magnetic resonance (NMR) spectroscopic techniques: 1H NMR and 13C NMR, heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), nuclear Overhauser effect spectroscopy (NOESY), and also the high-resolution electrospray ionization mass spectrometry (EI-HRMS). The cytotoxic activity of all alkaloids was evaluated against three human cancer cell lines (HCT-116, HL-60, OVCAR8 and SF-295) showing IC50 values ranging from 0.01 to 35.7 µM.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001001976
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001001976
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20150176
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.26 n.10 2015
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
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institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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