Detalhes bibliográficos
| Autor(a) principal: |
Carvalho,Kaline R. |
| Data de Publicação: |
2015 |
| Outros Autores: |
Silva,Alison B.,
Torres,Maria Conceição M.,
Pinto,Francisco Chagas L.,
Guimarães,Larissa A.,
Rocha,Danilo D.,
Silveira,Edilberto R.,
Costa-Lotufo,Letícia V.,
Braz‑Filho,Raimundo,
Pessoa,Otília Deusdênia. L. |
| Tipo de documento: |
Artigo
|
| Idioma: |
eng |
| Título da fonte: |
Journal of the Brazilian Chemical Society (Online) |
| Texto Completo: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001001976
|
Resumo: |
One new alkaloid, 2α-10bα-dihydroxy-9-O-demethylhomolycorine, in addition to seven others known alkaloids, and 5-(hydroxymethyl)furfural, piscidic acid and eucomic acid, were isolated from the bulbs of Hippeastrum solandriflorum. The structures of all compounds were determined using nuclear magnetic resonance (NMR) spectroscopic techniques: 1H NMR and 13C NMR, heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), nuclear Overhauser effect spectroscopy (NOESY), and also the high-resolution electrospray ionization mass spectrometry (EI-HRMS). The cytotoxic activity of all alkaloids was evaluated against three human cancer cell lines (HCT-116, HL-60, OVCAR8 and SF-295) showing IC50 values ranging from 0.01 to 35.7 µM. |