A compact miniaturized flow system based on low-temperature co-fired ceramic technology coupled to LED mini-photometer for determination of dipyrone in pharmaceutical formulations

• Autor(a) principal: Suarez,Willian T.
• Data de Publicação: 2013
• Outros Autores: Pessoa-Neto,Osmundo D., Santos,Vagner B. dos, Nogueira,Ana Rita de A., Faria,Ronaldo C., Fatibello-Filho,Orlando, Chamarro,Julián A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000500018
• topic: low-temperature co-fired ceramic; analytical microsystem; dipyrone; flow injection analysis; LED photometer

In this work, an analytical microsystem based on LTCC (low-temperature co-fired ceramic) technology with monolithic incorporation of an optical flow cell for determination of dipyrone in pharmaceuticals is described. The detection system is based on the formation of a blue chromophore between dipyrone and Fe(III) photometrically monitored at 630 nm using a lab-made LED mini-photometer constructed with a light emitting diode as a radiation source and a Si photodiode as a detector. The lab-made mini-photometer elaborated presented a good performance in regard to high signal/noise ratio, low drift and good sensitivity. The analytical curve was linear in the dipyrone concentration range from 1.0 × 10-4 to 3.5 × 10-3 mol L-1, limit of detection of 4.5 × 10-5 mol L-1 and total time of analyses of 20 s yielding an analytical frequency of 195 h-1 with a low waste generation per analysis (480 µL).