Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000901947 |
Resumo: | In this paper, a simple, sensitive and precise electroanalytical method was developed using a chemically-reduced graphene-oxide (CRGO)-modified glassy carbon electrode and square wave voltammetry (SWV) for determination of ciprofloxacin in pharmaceutical formulations (tablets) and milk samples. Advantages of this sensor include a potential displacement of 100 mV and a 5-fold current increase for the electrochemical oxidation of ciprofloxacin, which resulted in a highly sensitive sensor, when compared to unmodified electrode. The improved properties of the modified electrode are likely due to the formation of a porous surface evidenced by the change in electrode kinetics (thin-layer diffusion process). The proposed sensor is free from interference of sample matrix (pharmaceutical formulations and low/high-fat milk) avoiding cumbersome processes such as previous separations, solvent extraction, or sample filtration (samples were only diluted in Britton-Robinson buffer solution). The results by SWV showed a limit of detection of 0.21 µmol L-1 (correspondent to 0.069 mg L-1), which is lower than the ones obtained using other carbon-based electrodes, relative standard deviations lower than 12%, and satisfactory recoveries in the range from 84 to 109%. The results obtained were statistically similar (95% confidence level) with those performed through high-performance liquid chromatography (HPLC). |
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Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensorchemically-reduced graphene-oxideciprofloxacinpharmaceutical formulationsmilksquare wave voltammetryIn this paper, a simple, sensitive and precise electroanalytical method was developed using a chemically-reduced graphene-oxide (CRGO)-modified glassy carbon electrode and square wave voltammetry (SWV) for determination of ciprofloxacin in pharmaceutical formulations (tablets) and milk samples. Advantages of this sensor include a potential displacement of 100 mV and a 5-fold current increase for the electrochemical oxidation of ciprofloxacin, which resulted in a highly sensitive sensor, when compared to unmodified electrode. The improved properties of the modified electrode are likely due to the formation of a porous surface evidenced by the change in electrode kinetics (thin-layer diffusion process). The proposed sensor is free from interference of sample matrix (pharmaceutical formulations and low/high-fat milk) avoiding cumbersome processes such as previous separations, solvent extraction, or sample filtration (samples were only diluted in Britton-Robinson buffer solution). The results by SWV showed a limit of detection of 0.21 µmol L-1 (correspondent to 0.069 mg L-1), which is lower than the ones obtained using other carbon-based electrodes, relative standard deviations lower than 12%, and satisfactory recoveries in the range from 84 to 109%. The results obtained were statistically similar (95% confidence level) with those performed through high-performance liquid chromatography (HPLC).Sociedade Brasileira de Química2019-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000901947Journal of the Brazilian Chemical Society v.30 n.9 2019reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190108info:eu-repo/semantics/openAccessFaria,Lucas V.Pereira,Jian F. S.Azevedo,Gustavo C.Matos,Maria A. C.Munoz,Rodrigo A. A.Matos,Renato C.eng2019-09-11T00:00:00Zoai:scielo:S0103-50532019000901947Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2019-09-11T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor |
title |
Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor |
spellingShingle |
Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor Faria,Lucas V. chemically-reduced graphene-oxide ciprofloxacin pharmaceutical formulations milk square wave voltammetry |
title_short |
Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor |
title_full |
Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor |
title_fullStr |
Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor |
title_full_unstemmed |
Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor |
title_sort |
Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor |
author |
Faria,Lucas V. |
author_facet |
Faria,Lucas V. Pereira,Jian F. S. Azevedo,Gustavo C. Matos,Maria A. C. Munoz,Rodrigo A. A. Matos,Renato C. |
author_role |
author |
author2 |
Pereira,Jian F. S. Azevedo,Gustavo C. Matos,Maria A. C. Munoz,Rodrigo A. A. Matos,Renato C. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Faria,Lucas V. Pereira,Jian F. S. Azevedo,Gustavo C. Matos,Maria A. C. Munoz,Rodrigo A. A. Matos,Renato C. |
dc.subject.por.fl_str_mv |
chemically-reduced graphene-oxide ciprofloxacin pharmaceutical formulations milk square wave voltammetry |
topic |
chemically-reduced graphene-oxide ciprofloxacin pharmaceutical formulations milk square wave voltammetry |
description |
In this paper, a simple, sensitive and precise electroanalytical method was developed using a chemically-reduced graphene-oxide (CRGO)-modified glassy carbon electrode and square wave voltammetry (SWV) for determination of ciprofloxacin in pharmaceutical formulations (tablets) and milk samples. Advantages of this sensor include a potential displacement of 100 mV and a 5-fold current increase for the electrochemical oxidation of ciprofloxacin, which resulted in a highly sensitive sensor, when compared to unmodified electrode. The improved properties of the modified electrode are likely due to the formation of a porous surface evidenced by the change in electrode kinetics (thin-layer diffusion process). The proposed sensor is free from interference of sample matrix (pharmaceutical formulations and low/high-fat milk) avoiding cumbersome processes such as previous separations, solvent extraction, or sample filtration (samples were only diluted in Britton-Robinson buffer solution). The results by SWV showed a limit of detection of 0.21 µmol L-1 (correspondent to 0.069 mg L-1), which is lower than the ones obtained using other carbon-based electrodes, relative standard deviations lower than 12%, and satisfactory recoveries in the range from 84 to 109%. The results obtained were statistically similar (95% confidence level) with those performed through high-performance liquid chromatography (HPLC). |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000901947 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000901947 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20190108 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.30 n.9 2019 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
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1750318182147555328 |