Cytotoxic lipidic α-amino acids from the zoanthid Protopalythoa variabilis from the Northeastern coast of Brazil

• Autor(a) principal: Wilke,Diego Veras
• Data de Publicação: 2009
• Outros Autores: Jimenez,Paula Christine, Pessoa,Claudia, Moraes,Manoel Odorico de, Araújo,Renata Mendonça, Silva,Wildson Max Barbosa da, Silveira,Edilberto Rocha, Pessoa,Otília Deusdênia Loiola, Braz-Filho,Raimundo, Lopes,Norberto Peporine, Costa-Lotufo,Letícia Veras
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000800010
• topic: Protopalythoa variabilis; lipidic α-amino acids; cytotoxic activity

Two lipidic α-amino acids 1a and 1b were isolated from the zoanthid Protopalythoa variabilis using a bioguided fractionation for cytotoxic activity. The structures of the metabolites were determined by spectroscopic methods, including NMR (nuclear magnetic resonance) ¹H e 13C, IR (infrared) and high resolution mass spectrometry (positive mode). The cytotoxic activity of the crude extract, as well as of the mixture of 1a and 1b were measured in vitro using the MTT assay for four human tumor cell lines. This finding has important biological and chemical implications for this type of compound. This is the first report of lipidic α-amino acids from natural sources, as well as of their cytotoxic activity.