Chlorination of isatins with trichloroisocyanuric acid

Detalhes bibliográficos
Autor(a) principal: Silva,Bárbara V
Data de Publicação: 2011
Outros Autores: Esteves,Pierre M, Pinto,Angelo C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200010
Resumo: Isatin and its derivatives have been extensively reported in the literature as having range of potential pharmacological compounds. The Sandmeyer method is the most widely used for isatin synthesis and furnishes different substituted isatins, usually with high yields. Although efficient, the Sandmeyer route has certain limitations, such as the formation of a mixture of regiosiomers and low yields depending on the type and position of the substituent. Thus, overcome these limitations, it is preferable that some derivative isatins be obtained by alternative methods. This article has investigated the chlorination of isatin derivatives using trichloroisocyanuric acid [1,3,5-trichloro 1,3,5-triazine-2,4,6-(1H,3H,5H)-trione or TCCA] at different reaction conditions.
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spelling Chlorination of isatins with trichloroisocyanuric acidisatintrichloroisocyanuric acidchlorinationIsatin and its derivatives have been extensively reported in the literature as having range of potential pharmacological compounds. The Sandmeyer method is the most widely used for isatin synthesis and furnishes different substituted isatins, usually with high yields. Although efficient, the Sandmeyer route has certain limitations, such as the formation of a mixture of regiosiomers and low yields depending on the type and position of the substituent. Thus, overcome these limitations, it is preferable that some derivative isatins be obtained by alternative methods. This article has investigated the chlorination of isatin derivatives using trichloroisocyanuric acid [1,3,5-trichloro 1,3,5-triazine-2,4,6-(1H,3H,5H)-trione or TCCA] at different reaction conditions.Sociedade Brasileira de Química2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200010Journal of the Brazilian Chemical Society v.22 n.2 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011000200010info:eu-repo/semantics/openAccessSilva,Bárbara VEsteves,Pierre MPinto,Angelo Ceng2011-02-14T00:00:00Zoai:scielo:S0103-50532011000200010Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-02-14T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Chlorination of isatins with trichloroisocyanuric acid
title Chlorination of isatins with trichloroisocyanuric acid
spellingShingle Chlorination of isatins with trichloroisocyanuric acid
Silva,Bárbara V
isatin
trichloroisocyanuric acid
chlorination
title_short Chlorination of isatins with trichloroisocyanuric acid
title_full Chlorination of isatins with trichloroisocyanuric acid
title_fullStr Chlorination of isatins with trichloroisocyanuric acid
title_full_unstemmed Chlorination of isatins with trichloroisocyanuric acid
title_sort Chlorination of isatins with trichloroisocyanuric acid
author Silva,Bárbara V
author_facet Silva,Bárbara V
Esteves,Pierre M
Pinto,Angelo C
author_role author
author2 Esteves,Pierre M
Pinto,Angelo C
author2_role author
author
dc.contributor.author.fl_str_mv Silva,Bárbara V
Esteves,Pierre M
Pinto,Angelo C
dc.subject.por.fl_str_mv isatin
trichloroisocyanuric acid
chlorination
topic isatin
trichloroisocyanuric acid
chlorination
description Isatin and its derivatives have been extensively reported in the literature as having range of potential pharmacological compounds. The Sandmeyer method is the most widely used for isatin synthesis and furnishes different substituted isatins, usually with high yields. Although efficient, the Sandmeyer route has certain limitations, such as the formation of a mixture of regiosiomers and low yields depending on the type and position of the substituent. Thus, overcome these limitations, it is preferable that some derivative isatins be obtained by alternative methods. This article has investigated the chlorination of isatin derivatives using trichloroisocyanuric acid [1,3,5-trichloro 1,3,5-triazine-2,4,6-(1H,3H,5H)-trione or TCCA] at different reaction conditions.
publishDate 2011
dc.date.none.fl_str_mv 2011-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532011000200010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.22 n.2 2011
reponame:Journal of the Brazilian Chemical Society (Online)
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collection Journal of the Brazilian Chemical Society (Online)
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