Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography

Detalhes bibliográficos
Autor(a) principal: Hancu,Gabriel
Data de Publicação: 2012
Outros Autores: Rusu,Aura, Simon,Brigitta, Boia,Georgiana, Gyéresi,Árpád
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012001000018
Resumo: This work describes the development of a simple capillary electrophoresis (CE) method for simultaneous determination of the three most frequently used fluoroquinolone derivatives: ciprofloxacin, norfloxacin and ofloxacin. Due to very similar structural and physicochemical characteristics, ciprofloxacin and norfloxacin cannot be separated by the classic method of capillary zone electrophoresis (CZE). Their separations can be solved using micellar electrokinetic chromatography (MEKC), by adding an anionic surfactant to the buffer solution. The efficiency of the separation can be enhanced through the optimization of analytical parameters. A fast reliable method was developed, and the best results were obtained using a buffer solution containing 25 mmol L-1 sodium tetraborate, 100 mmol L-1 sodium dodecyl sulphate and 5% methanol as organic modifier.
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spelling Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatographyfluoroquinolonesmicellar electrokinetic chromatographyciprofloxacinnorfloxacinofloxacinThis work describes the development of a simple capillary electrophoresis (CE) method for simultaneous determination of the three most frequently used fluoroquinolone derivatives: ciprofloxacin, norfloxacin and ofloxacin. Due to very similar structural and physicochemical characteristics, ciprofloxacin and norfloxacin cannot be separated by the classic method of capillary zone electrophoresis (CZE). Their separations can be solved using micellar electrokinetic chromatography (MEKC), by adding an anionic surfactant to the buffer solution. The efficiency of the separation can be enhanced through the optimization of analytical parameters. A fast reliable method was developed, and the best results were obtained using a buffer solution containing 25 mmol L-1 sodium tetraborate, 100 mmol L-1 sodium dodecyl sulphate and 5% methanol as organic modifier.Sociedade Brasileira de Química2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012001000018Journal of the Brazilian Chemical Society v.23 n.10 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012005000057info:eu-repo/semantics/openAccessHancu,GabrielRusu,AuraSimon,BrigittaBoia,GeorgianaGyéresi,Árpádeng2012-12-05T00:00:00Zoai:scielo:S0103-50532012001000018Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-12-05T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography
title Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography
spellingShingle Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography
Hancu,Gabriel
fluoroquinolones
micellar electrokinetic chromatography
ciprofloxacin
norfloxacin
ofloxacin
title_short Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography
title_full Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography
title_fullStr Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography
title_full_unstemmed Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography
title_sort Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography
author Hancu,Gabriel
author_facet Hancu,Gabriel
Rusu,Aura
Simon,Brigitta
Boia,Georgiana
Gyéresi,Árpád
author_role author
author2 Rusu,Aura
Simon,Brigitta
Boia,Georgiana
Gyéresi,Árpád
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Hancu,Gabriel
Rusu,Aura
Simon,Brigitta
Boia,Georgiana
Gyéresi,Árpád
dc.subject.por.fl_str_mv fluoroquinolones
micellar electrokinetic chromatography
ciprofloxacin
norfloxacin
ofloxacin
topic fluoroquinolones
micellar electrokinetic chromatography
ciprofloxacin
norfloxacin
ofloxacin
description This work describes the development of a simple capillary electrophoresis (CE) method for simultaneous determination of the three most frequently used fluoroquinolone derivatives: ciprofloxacin, norfloxacin and ofloxacin. Due to very similar structural and physicochemical characteristics, ciprofloxacin and norfloxacin cannot be separated by the classic method of capillary zone electrophoresis (CZE). Their separations can be solved using micellar electrokinetic chromatography (MEKC), by adding an anionic surfactant to the buffer solution. The efficiency of the separation can be enhanced through the optimization of analytical parameters. A fast reliable method was developed, and the best results were obtained using a buffer solution containing 25 mmol L-1 sodium tetraborate, 100 mmol L-1 sodium dodecyl sulphate and 5% methanol as organic modifier.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012001000018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012001000018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532012005000057
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.23 n.10 2012
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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