Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolide

Detalhes bibliográficos
Autor(a) principal: Magaton,Andréia da Silva
Data de Publicação: 2007
Outros Autores: Rubinger,Mayura M. M., Macedo Júnior,Fernando C. de, Zambolim,Laércio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000200007
Resumo: In a study of the antifungal activity of selected compounds as potentials agrochemicals, we have prepared and characterized by elemental analyses, infrared and NMR spectroscopies three new bis-gamma-lactones analogous to avenaciolide, where the octyl group of this natural product was replaced by heptyl, hexyl and pentyl groups. The effects on the mycelia development and conidia germination of Colletotrichum gloesporioides of these compounds and their synthetic precursors were evaluated in vitro. The title compounds were active in the tested conditions, while all the synthetic precursors were inactive. The preparation and characterization of 15 new synthetic intermediates are also described.
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spelling Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolidebis-gamma-lactonesantifungal activityColletotrichum gloesporioidesIn a study of the antifungal activity of selected compounds as potentials agrochemicals, we have prepared and characterized by elemental analyses, infrared and NMR spectroscopies three new bis-gamma-lactones analogous to avenaciolide, where the octyl group of this natural product was replaced by heptyl, hexyl and pentyl groups. The effects on the mycelia development and conidia germination of Colletotrichum gloesporioides of these compounds and their synthetic precursors were evaluated in vitro. The title compounds were active in the tested conditions, while all the synthetic precursors were inactive. The preparation and characterization of 15 new synthetic intermediates are also described.Sociedade Brasileira de Química2007-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000200007Journal of the Brazilian Chemical Society v.18 n.2 2007reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532007000200007info:eu-repo/semantics/openAccessMagaton,Andréia da SilvaRubinger,Mayura M. M.Macedo Júnior,Fernando C. deZambolim,Laércioeng2007-06-13T00:00:00Zoai:scielo:S0103-50532007000200007Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2007-06-13T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolide
title Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolide
spellingShingle Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolide
Magaton,Andréia da Silva
bis-gamma-lactones
antifungal activity
Colletotrichum gloesporioides
title_short Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolide
title_full Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolide
title_fullStr Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolide
title_full_unstemmed Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolide
title_sort Synthesis and antifungal activity of new bis-gamma-lactones analogous to avenaciolide
author Magaton,Andréia da Silva
author_facet Magaton,Andréia da Silva
Rubinger,Mayura M. M.
Macedo Júnior,Fernando C. de
Zambolim,Laércio
author_role author
author2 Rubinger,Mayura M. M.
Macedo Júnior,Fernando C. de
Zambolim,Laércio
author2_role author
author
author
dc.contributor.author.fl_str_mv Magaton,Andréia da Silva
Rubinger,Mayura M. M.
Macedo Júnior,Fernando C. de
Zambolim,Laércio
dc.subject.por.fl_str_mv bis-gamma-lactones
antifungal activity
Colletotrichum gloesporioides
topic bis-gamma-lactones
antifungal activity
Colletotrichum gloesporioides
description In a study of the antifungal activity of selected compounds as potentials agrochemicals, we have prepared and characterized by elemental analyses, infrared and NMR spectroscopies three new bis-gamma-lactones analogous to avenaciolide, where the octyl group of this natural product was replaced by heptyl, hexyl and pentyl groups. The effects on the mycelia development and conidia germination of Colletotrichum gloesporioides of these compounds and their synthetic precursors were evaluated in vitro. The title compounds were active in the tested conditions, while all the synthetic precursors were inactive. The preparation and characterization of 15 new synthetic intermediates are also described.
publishDate 2007
dc.date.none.fl_str_mv 2007-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000200007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532007000200007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.18 n.2 2007
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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