Determination of endocrine disrupters and pharmaceuticals in sewage samples by tandem solid phase clean up/extraction and high performance liquid chromatography-negative and positive electrospray high-resolution mass spectrometry

• Autor(a) principal: Queiroz,Fernanda B.
• Data de Publicação: 2014
• Outros Autores: Silva,Júlio C., Aquino,Sérgio F., Coutrim,Maurício X., Afonso,Robson J. C. F.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000200013
• topic: pharmaceuticals; endocrine disrupters; high performance liquid chromatography tandem mass spectrometry; solid phase extraction; sewage

A new method for the determination of three endocrine disrupters (estradiol, ethinyl estradiol, and bisphenol A) and five pharmaceuticals (sulfamethoxazole, trimethoprim, diclofenac, bezafibrate and miconazole) in raw sewage samples using tandem solid phase extraction (SPE) sorbents and high-performance liquid chromatography-negative and positive electrospray high-resolution mass spectrometry (HPLC-HRMS) was developed and validated. The SPE procedure used both a strong ion exchange sorbent (SAX) and a modified divinylbenzene-pyrrolidone SPE sorbent to reduce the levels of linear alkylbenzene sulfonate (LAS) and to concentrate the analytes of interest from the sewage samples. The influence of matrix composition on the ionisation efficiency, the SPE recoveries, and the sensitivity of the method was identified and quantified. The method was successfully applied to the determination of analytes in raw sewage samples collected from the entrance of the Arrudas Sewage Treatment Plant, Belo Horizonte, Brazil.