Multi-gram Preparation of 7-Nitroquinoxalin-2-amine

• Autor(a) principal: Amaral,Daniel N. do
• Data de Publicação: 2017
• Outros Autores: Alves,Fernando R. de Sá, Barreiro,Eliezer J., Laufer,Stefan A., Lima,Lídia M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001001874
• topic: quinoxaline; 7-nitroquinoxaline-2-amine; regioselective nitration

Methodologies to obtain quinoxaline compounds regioselectively are rarely reported in literature, thus regioselective and multi-gram methodologies to obtain these derivatives are desirable to explore the entire potential of these scaffolds for academic and/or commercial application. A facile and multi-gram methodology is described to obtain compound 7-nitroquinoxalin-2-amine using o-phenylenediamine, a cheap and readily available reactant, as starting material in a five-step procedure in good yields and high purity without further purification such as crystallization or column chromatography.