Physicochemical and morphological characterizations of glyceryl tristearate/castor oil nanocarriers prepared by the solvent diffusion method

• Autor(a) principal: Dora,Cristiana L.
• Data de Publicação: 2012
• Outros Autores: Putaux,Jean-Luc, Pignot-Paintrand,Isabelle, Dubreuil,Frédéric, Soldi,Valdir, Borsali,Redouane, Lemos-Senna,Elenara
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012001100003
• topic: solid lipid nanoparticles; nanostructured lipid carriers; nanoemulsions; structural investigation; drug delivery systems

In this study, drug delivery nanocarriers based on glyceryl tristearate and castor oil at different ratios were prepared by the hot solvent diffusion method. PEG 660-stearate or Poloxamer 188 and soybean lecithin were used as surfactant and co-surfactant, respectively. Structural and physicochemical characteristics of the particles were investigated by means of dynamic light scattering (DLS), differential scanning calorimetry (DSC), wide-angle X-ray scattering (WAXS), atomic force microscopy (AFM) and transmission electron microscopy (TEM and cryo-TEM). DLS data indicated that smaller particles were obtained when the liquid lipid was used alone to prepare nanoemulsions (NEs). TEM and cryo-TEM images showed that NEs presented spherical particles, whereas solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) presented more complex shapes. SLNs exhibited lamellar crystal structure, while NLCs displayed a hybrid structure composed of a lamellar crystalline phase in contact with a liquid oil compartment. These experiments contribute to a better understanding of the structure and release performance of these drug carrier systems.