LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions

Detalhes bibliográficos
Autor(a) principal: Ruela,André L. M.
Data de Publicação: 2014
Outros Autores: Santos,Mariane G., Figueiredo,Eduardo C., Pereira,Gislaine R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001100022
Resumo: The aim of this work was to study the intrinsic stability of donepezil hydrochloride in conditions of forced degradation (acid stress, alkaline stress, oxidant stress, light exposure and dry heat). The degradation profile of donepezil was characterized by liquid chromatography-mass spectrometry (LC-MS) and high-performance liquid chromatography coupled with photodiode array detection (LC-PDA). According to the results, the degradation products were separated and detected in acid and alkaline solutions. After seven days at room temperature, the recovery of donepezil in alkaline solution (0.1 mol L-1 NaOH) was about 42%, and three degradation products were detected. In acid solution (0.1 mol L-1 HCl), the drug recovery was about 86%, and three degradation products were detected. Thus, it was possible to propose a rapid and selective stability-indicating assay method using reversed-phase liquid chromatography for analysis of donepezil and their degradation products.
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spelling LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditionsdonepezil hydrochlorideintrinsic stabilitydegradation studiesliquid chromatographymass spectrometryThe aim of this work was to study the intrinsic stability of donepezil hydrochloride in conditions of forced degradation (acid stress, alkaline stress, oxidant stress, light exposure and dry heat). The degradation profile of donepezil was characterized by liquid chromatography-mass spectrometry (LC-MS) and high-performance liquid chromatography coupled with photodiode array detection (LC-PDA). According to the results, the degradation products were separated and detected in acid and alkaline solutions. After seven days at room temperature, the recovery of donepezil in alkaline solution (0.1 mol L-1 NaOH) was about 42%, and three degradation products were detected. In acid solution (0.1 mol L-1 HCl), the drug recovery was about 86%, and three degradation products were detected. Thus, it was possible to propose a rapid and selective stability-indicating assay method using reversed-phase liquid chromatography for analysis of donepezil and their degradation products.Sociedade Brasileira de Química2014-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001100022Journal of the Brazilian Chemical Society v.25 n.11 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140199info:eu-repo/semantics/openAccessRuela,André L. M.Santos,Mariane G.Figueiredo,Eduardo C.Pereira,Gislaine R.eng2014-11-13T00:00:00Zoai:scielo:S0103-50532014001100022Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-11-13T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions
title LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions
spellingShingle LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions
Ruela,André L. M.
donepezil hydrochloride
intrinsic stability
degradation studies
liquid chromatography
mass spectrometry
title_short LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions
title_full LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions
title_fullStr LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions
title_full_unstemmed LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions
title_sort LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions
author Ruela,André L. M.
author_facet Ruela,André L. M.
Santos,Mariane G.
Figueiredo,Eduardo C.
Pereira,Gislaine R.
author_role author
author2 Santos,Mariane G.
Figueiredo,Eduardo C.
Pereira,Gislaine R.
author2_role author
author
author
dc.contributor.author.fl_str_mv Ruela,André L. M.
Santos,Mariane G.
Figueiredo,Eduardo C.
Pereira,Gislaine R.
dc.subject.por.fl_str_mv donepezil hydrochloride
intrinsic stability
degradation studies
liquid chromatography
mass spectrometry
topic donepezil hydrochloride
intrinsic stability
degradation studies
liquid chromatography
mass spectrometry
description The aim of this work was to study the intrinsic stability of donepezil hydrochloride in conditions of forced degradation (acid stress, alkaline stress, oxidant stress, light exposure and dry heat). The degradation profile of donepezil was characterized by liquid chromatography-mass spectrometry (LC-MS) and high-performance liquid chromatography coupled with photodiode array detection (LC-PDA). According to the results, the degradation products were separated and detected in acid and alkaline solutions. After seven days at room temperature, the recovery of donepezil in alkaline solution (0.1 mol L-1 NaOH) was about 42%, and three degradation products were detected. In acid solution (0.1 mol L-1 HCl), the drug recovery was about 86%, and three degradation products were detected. Thus, it was possible to propose a rapid and selective stability-indicating assay method using reversed-phase liquid chromatography for analysis of donepezil and their degradation products.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001100022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001100022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20140199
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.25 n.11 2014
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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