Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems

Detalhes bibliográficos
Autor(a) principal: Lopes,Raquel O.
Data de Publicação: 2015
Outros Autores: Grimm,Simon, Ribeiro,Joyce B., Leal,Ivana C. R., Miranda,Leandro S. M., Souza,Rodrigo O. M. A. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000300550
Resumo: Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess.
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spelling Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systemswhole cell bioreductionpacked bed reactorcontinuous flowasymmetric reductionPacked bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess.Sociedade Brasileira de Química2015-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000300550Journal of the Brazilian Chemical Society v.26 n.3 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150009info:eu-repo/semantics/openAccessLopes,Raquel O.Grimm,SimonRibeiro,Joyce B.Leal,Ivana C. R.Miranda,Leandro S. M.Souza,Rodrigo O. M. A. deeng2017-11-09T00:00:00Zoai:scielo:S0103-50532015000300550Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2017-11-09T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
spellingShingle Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
Lopes,Raquel O.
whole cell bioreduction
packed bed reactor
continuous flow
asymmetric reduction
title_short Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title_full Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title_fullStr Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title_full_unstemmed Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title_sort Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
author Lopes,Raquel O.
author_facet Lopes,Raquel O.
Grimm,Simon
Ribeiro,Joyce B.
Leal,Ivana C. R.
Miranda,Leandro S. M.
Souza,Rodrigo O. M. A. de
author_role author
author2 Grimm,Simon
Ribeiro,Joyce B.
Leal,Ivana C. R.
Miranda,Leandro S. M.
Souza,Rodrigo O. M. A. de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes,Raquel O.
Grimm,Simon
Ribeiro,Joyce B.
Leal,Ivana C. R.
Miranda,Leandro S. M.
Souza,Rodrigo O. M. A. de
dc.subject.por.fl_str_mv whole cell bioreduction
packed bed reactor
continuous flow
asymmetric reduction
topic whole cell bioreduction
packed bed reactor
continuous flow
asymmetric reduction
description Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000300550
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000300550
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20150009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.26 n.3 2015
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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