Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®

Detalhes bibliográficos
Autor(a) principal: Dutra,Lillian M. U.
Data de Publicação: 2017
Outros Autores: Cavalcante,Igor M., Brito,Débora H. A. de, Vieira,Ícaro G. P., Trevisan,Maria T. S., Ribeiro,Maria E. N. P., Yeates,Stephen G., Ricardo,Nágila M. P. S.
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000701341
Resumo: Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127(®)) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.
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spelling Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®poly(ε-caprolactone)-poly(ethylene oxide)binary mixturessynergistic effectdrug solubilityBinary mixtures of block copolymers E114CL20 and E97P69E97 (F127(®)) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.Sociedade Brasileira de Química2017-07-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000701341Journal of the Brazilian Chemical Society v.28 n.7 2017reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20160302info:eu-repo/semantics/openAccessDutra,Lillian M. U.Cavalcante,Igor M.Brito,Débora H. A. deVieira,Ícaro G. P.Trevisan,Maria T. S.Ribeiro,Maria E. N. P.Yeates,Stephen G.Ricardo,Nágila M. P. S.eng2017-06-23T00:00:00Zoai:scielo:S0103-50532017000701341Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2017-06-23T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®
title Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®
spellingShingle Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®
Dutra,Lillian M. U.
poly(ε-caprolactone)-poly(ethylene oxide)
binary mixtures
synergistic effect
drug solubility
title_short Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®
title_full Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®
title_fullStr Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®
title_full_unstemmed Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®
title_sort Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®
author Dutra,Lillian M. U.
author_facet Dutra,Lillian M. U.
Cavalcante,Igor M.
Brito,Débora H. A. de
Vieira,Ícaro G. P.
Trevisan,Maria T. S.
Ribeiro,Maria E. N. P.
Yeates,Stephen G.
Ricardo,Nágila M. P. S.
author_role author
author2 Cavalcante,Igor M.
Brito,Débora H. A. de
Vieira,Ícaro G. P.
Trevisan,Maria T. S.
Ribeiro,Maria E. N. P.
Yeates,Stephen G.
Ricardo,Nágila M. P. S.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dutra,Lillian M. U.
Cavalcante,Igor M.
Brito,Débora H. A. de
Vieira,Ícaro G. P.
Trevisan,Maria T. S.
Ribeiro,Maria E. N. P.
Yeates,Stephen G.
Ricardo,Nágila M. P. S.
dc.subject.por.fl_str_mv poly(ε-caprolactone)-poly(ethylene oxide)
binary mixtures
synergistic effect
drug solubility
topic poly(ε-caprolactone)-poly(ethylene oxide)
binary mixtures
synergistic effect
drug solubility
description Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127(®)) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.
publishDate 2017
dc.date.none.fl_str_mv 2017-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000701341
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000701341
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0103-5053.20160302
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.28 n.7 2017
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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