Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation

Detalhes bibliográficos
Autor(a) principal: Belinelo,Valdenir J.
Data de Publicação: 2002
Outros Autores: Reis,Genuína T., Stefani,Guglielmo M., Ferreira-Alves,Dalton L., Piló-Veloso,Dorila
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600016
Resumo: The furanditerpene 6a,7b-dihydroxyvouacapan-17b-oic acid (ADV, 1), isolated from Pterodon polygalaeflorus Benth fruits, presents analgesic activity in current rodent experimental models. With the aim to gather data for biological studies it were obtained six new amide derivatives substituted in the furan ring with alkylamine groups, prepared by the Mannich reaction with preformed iminium salts. These derivatives were evaluated in a preliminary in vitro pharmacological test. Structures were determined by spectroscopic data of IR, ¹H and 13C NMR.
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spelling Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparationfuranditerpenesvouacapanoidsPterodon polygalaeflorusanalgesicsMannich basesThe furanditerpene 6a,7b-dihydroxyvouacapan-17b-oic acid (ADV, 1), isolated from Pterodon polygalaeflorus Benth fruits, presents analgesic activity in current rodent experimental models. With the aim to gather data for biological studies it were obtained six new amide derivatives substituted in the furan ring with alkylamine groups, prepared by the Mannich reaction with preformed iminium salts. These derivatives were evaluated in a preliminary in vitro pharmacological test. Structures were determined by spectroscopic data of IR, ¹H and 13C NMR.Sociedade Brasileira de Química2002-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600016Journal of the Brazilian Chemical Society v.13 n.6 2002reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532002000600016info:eu-repo/semantics/openAccessBelinelo,Valdenir J.Reis,Genuína T.Stefani,Guglielmo M.Ferreira-Alves,Dalton L.Piló-Veloso,Dorilaeng2015-11-26T00:00:00Zoai:scielo:S0103-50532002000600016Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-11-26T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation
title Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation
spellingShingle Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation
Belinelo,Valdenir J.
furanditerpenes
vouacapanoids
Pterodon polygalaeflorus
analgesics
Mannich bases
title_short Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation
title_full Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation
title_fullStr Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation
title_full_unstemmed Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation
title_sort Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation
author Belinelo,Valdenir J.
author_facet Belinelo,Valdenir J.
Reis,Genuína T.
Stefani,Guglielmo M.
Ferreira-Alves,Dalton L.
Piló-Veloso,Dorila
author_role author
author2 Reis,Genuína T.
Stefani,Guglielmo M.
Ferreira-Alves,Dalton L.
Piló-Veloso,Dorila
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Belinelo,Valdenir J.
Reis,Genuína T.
Stefani,Guglielmo M.
Ferreira-Alves,Dalton L.
Piló-Veloso,Dorila
dc.subject.por.fl_str_mv furanditerpenes
vouacapanoids
Pterodon polygalaeflorus
analgesics
Mannich bases
topic furanditerpenes
vouacapanoids
Pterodon polygalaeflorus
analgesics
Mannich bases
description The furanditerpene 6a,7b-dihydroxyvouacapan-17b-oic acid (ADV, 1), isolated from Pterodon polygalaeflorus Benth fruits, presents analgesic activity in current rodent experimental models. With the aim to gather data for biological studies it were obtained six new amide derivatives substituted in the furan ring with alkylamine groups, prepared by the Mannich reaction with preformed iminium salts. These derivatives were evaluated in a preliminary in vitro pharmacological test. Structures were determined by spectroscopic data of IR, ¹H and 13C NMR.
publishDate 2002
dc.date.none.fl_str_mv 2002-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532002000600016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.13 n.6 2002
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
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instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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