Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis

Detalhes bibliográficos
Autor(a) principal: Simões,Simone S.
Data de Publicação: 2006
Outros Autores: Medeiros,Everaldo P., Gaião,Edvaldo N., Lyra,Wellington S., Moreira,Pablo N. T., Araújo,Mario C. U., Silva,Edvan C., Nascimento,Valberes B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300028
Resumo: A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from common ingredients accompanying the drug.
id SBQ-2_8e8cb16415ee6351eaf44987365aba8c
oai_identifier_str oai:scielo:S0103-50532006000300028
network_acronym_str SBQ-2
network_name_str Journal of the Brazilian Chemical Society (Online)
repository_id_str
spelling Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysisflow injection analysisspectrophotometrypharmaceuticalsmetronidazolenitriteA new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from common ingredients accompanying the drug.Sociedade Brasileira de Química2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300028Journal of the Brazilian Chemical Society v.17 n.3 2006reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532006000300028info:eu-repo/semantics/openAccessSimões,Simone S.Medeiros,Everaldo P.Gaião,Edvaldo N.Lyra,Wellington S.Moreira,Pablo N. T.Araújo,Mario C. U.Silva,Edvan C.Nascimento,Valberes B.eng2006-05-25T00:00:00Zoai:scielo:S0103-50532006000300028Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2006-05-25T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis
title Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis
spellingShingle Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis
Simões,Simone S.
flow injection analysis
spectrophotometry
pharmaceuticals
metronidazole
nitrite
title_short Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis
title_full Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis
title_fullStr Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis
title_full_unstemmed Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis
title_sort Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis
author Simões,Simone S.
author_facet Simões,Simone S.
Medeiros,Everaldo P.
Gaião,Edvaldo N.
Lyra,Wellington S.
Moreira,Pablo N. T.
Araújo,Mario C. U.
Silva,Edvan C.
Nascimento,Valberes B.
author_role author
author2 Medeiros,Everaldo P.
Gaião,Edvaldo N.
Lyra,Wellington S.
Moreira,Pablo N. T.
Araújo,Mario C. U.
Silva,Edvan C.
Nascimento,Valberes B.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Simões,Simone S.
Medeiros,Everaldo P.
Gaião,Edvaldo N.
Lyra,Wellington S.
Moreira,Pablo N. T.
Araújo,Mario C. U.
Silva,Edvan C.
Nascimento,Valberes B.
dc.subject.por.fl_str_mv flow injection analysis
spectrophotometry
pharmaceuticals
metronidazole
nitrite
topic flow injection analysis
spectrophotometry
pharmaceuticals
metronidazole
nitrite
description A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from common ingredients accompanying the drug.
publishDate 2006
dc.date.none.fl_str_mv 2006-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300028
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300028
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532006000300028
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.17 n.3 2006
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
_version_ 1750318167039672320

Registros relacionados