Design and cytotoxic evaluation of new annonaceous acetogenin analogues

Detalhes bibliográficos
Autor(a) principal: Krauss,Jürgen
Data de Publicação: 2007
Outros Autores: Bracher,Franz, Synowitz,Katrin, Unterreitmeier,Doris
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000400004
Resumo: Analogues of annonaceous acetogenins were built up from 5-iodofuran-2-carbaldehyde and undec-10-ynoic acid or undec-10-ynol by a Sonogashira reaction, followed by a Grignard reaction and a mercury catalysed hydratisation. The cytotoxicity was evaluated with MTT assay ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay for measuring cellular proliferation) against HL cells and at the National Cancer Institute (NCI).
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spelling Design and cytotoxic evaluation of new annonaceous acetogenin analoguesSonogashira reactionGrignard reactioncytotoxicityAnalogues of annonaceous acetogenins were built up from 5-iodofuran-2-carbaldehyde and undec-10-ynoic acid or undec-10-ynol by a Sonogashira reaction, followed by a Grignard reaction and a mercury catalysed hydratisation. The cytotoxicity was evaluated with MTT assay ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay for measuring cellular proliferation) against HL cells and at the National Cancer Institute (NCI).Sociedade Brasileira de Química2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000400004Journal of the Brazilian Chemical Society v.18 n.4 2007reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532007000400004info:eu-repo/semantics/openAccessKrauss,JürgenBracher,FranzSynowitz,KatrinUnterreitmeier,Doriseng2007-09-18T00:00:00Zoai:scielo:S0103-50532007000400004Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2007-09-18T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Design and cytotoxic evaluation of new annonaceous acetogenin analogues
title Design and cytotoxic evaluation of new annonaceous acetogenin analogues
spellingShingle Design and cytotoxic evaluation of new annonaceous acetogenin analogues
Krauss,Jürgen
Sonogashira reaction
Grignard reaction
cytotoxicity
title_short Design and cytotoxic evaluation of new annonaceous acetogenin analogues
title_full Design and cytotoxic evaluation of new annonaceous acetogenin analogues
title_fullStr Design and cytotoxic evaluation of new annonaceous acetogenin analogues
title_full_unstemmed Design and cytotoxic evaluation of new annonaceous acetogenin analogues
title_sort Design and cytotoxic evaluation of new annonaceous acetogenin analogues
author Krauss,Jürgen
author_facet Krauss,Jürgen
Bracher,Franz
Synowitz,Katrin
Unterreitmeier,Doris
author_role author
author2 Bracher,Franz
Synowitz,Katrin
Unterreitmeier,Doris
author2_role author
author
author
dc.contributor.author.fl_str_mv Krauss,Jürgen
Bracher,Franz
Synowitz,Katrin
Unterreitmeier,Doris
dc.subject.por.fl_str_mv Sonogashira reaction
Grignard reaction
cytotoxicity
topic Sonogashira reaction
Grignard reaction
cytotoxicity
description Analogues of annonaceous acetogenins were built up from 5-iodofuran-2-carbaldehyde and undec-10-ynoic acid or undec-10-ynol by a Sonogashira reaction, followed by a Grignard reaction and a mercury catalysed hydratisation. The cytotoxicity was evaluated with MTT assay ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay for measuring cellular proliferation) against HL cells and at the National Cancer Institute (NCI).
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000400004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000400004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532007000400004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.18 n.4 2007
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
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reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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