Antithyroid activity of 6-chloropurine

Detalhes bibliográficos
Autor(a) principal: Fatima,Ismat
Data de Publicação: 2010
Outros Autores: Munawar,Munawar A, Khan,Misbahul A, Asmatullah, Tasneem,Afia, Khalil,Muhammad
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000900015
Resumo: Antithyroid activity of 6-chloropurine was determined, in vitro, by studying its complex formation with iodine spectrophotometrically. The complex exhibited a 1:1 stoichiometry. Formation constant (Kc) of the complex was found to be 7.652 × 10³ L mol-1, which indicated good antithyroid potential of 6-chloropurine. For further verification, changes in the thyroid hormone levels of the male rabbits were observed, in vivo, after administering the dose through intra peritoneal (i.p.) injections for 14 days and measuring free triiodothyronine (T3) and tetraiodothyronine (T4) levels in the blood serum using radioimmunoassay technique. The blood assays showed decrease in free T3 and T4 levels in the treated animals as compared to the control ones thus confirming fairly good antithyroid activity of 6-choloropurine.
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spelling Antithyroid activity of 6-chloropurine6-chloro-9H-purineiodineantithyroid activitycharge transfer complexthyroid hormonesAntithyroid activity of 6-chloropurine was determined, in vitro, by studying its complex formation with iodine spectrophotometrically. The complex exhibited a 1:1 stoichiometry. Formation constant (Kc) of the complex was found to be 7.652 × 10³ L mol-1, which indicated good antithyroid potential of 6-chloropurine. For further verification, changes in the thyroid hormone levels of the male rabbits were observed, in vivo, after administering the dose through intra peritoneal (i.p.) injections for 14 days and measuring free triiodothyronine (T3) and tetraiodothyronine (T4) levels in the blood serum using radioimmunoassay technique. The blood assays showed decrease in free T3 and T4 levels in the treated animals as compared to the control ones thus confirming fairly good antithyroid activity of 6-choloropurine.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000900015Journal of the Brazilian Chemical Society v.21 n.9 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000900015info:eu-repo/semantics/openAccessFatima,IsmatMunawar,Munawar AKhan,Misbahul AAsmatullah,Tasneem,AfiaKhalil,Muhammadeng2010-09-13T00:00:00Zoai:scielo:S0103-50532010000900015Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-09-13T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Antithyroid activity of 6-chloropurine
title Antithyroid activity of 6-chloropurine
spellingShingle Antithyroid activity of 6-chloropurine
Fatima,Ismat
6-chloro-9H-purine
iodine
antithyroid activity
charge transfer complex
thyroid hormones
title_short Antithyroid activity of 6-chloropurine
title_full Antithyroid activity of 6-chloropurine
title_fullStr Antithyroid activity of 6-chloropurine
title_full_unstemmed Antithyroid activity of 6-chloropurine
title_sort Antithyroid activity of 6-chloropurine
author Fatima,Ismat
author_facet Fatima,Ismat
Munawar,Munawar A
Khan,Misbahul A
Asmatullah,
Tasneem,Afia
Khalil,Muhammad
author_role author
author2 Munawar,Munawar A
Khan,Misbahul A
Asmatullah,
Tasneem,Afia
Khalil,Muhammad
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Fatima,Ismat
Munawar,Munawar A
Khan,Misbahul A
Asmatullah,
Tasneem,Afia
Khalil,Muhammad
dc.subject.por.fl_str_mv 6-chloro-9H-purine
iodine
antithyroid activity
charge transfer complex
thyroid hormones
topic 6-chloro-9H-purine
iodine
antithyroid activity
charge transfer complex
thyroid hormones
description Antithyroid activity of 6-chloropurine was determined, in vitro, by studying its complex formation with iodine spectrophotometrically. The complex exhibited a 1:1 stoichiometry. Formation constant (Kc) of the complex was found to be 7.652 × 10³ L mol-1, which indicated good antithyroid potential of 6-chloropurine. For further verification, changes in the thyroid hormone levels of the male rabbits were observed, in vivo, after administering the dose through intra peritoneal (i.p.) injections for 14 days and measuring free triiodothyronine (T3) and tetraiodothyronine (T4) levels in the blood serum using radioimmunoassay technique. The blood assays showed decrease in free T3 and T4 levels in the treated animals as compared to the control ones thus confirming fairly good antithyroid activity of 6-choloropurine.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000900015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000900015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010000900015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.9 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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