Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbital
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000400833 |
Resumo: | This research presents a fast, sensitive, and selective ultrasound-assisted dispersive solid phase microextraction technique for simultaneous preconcentration and determination of ultra-trace amount of carbamazepine and phenobarbital. Reduced graphene oxide sheets decorated with cadmium sulfide quantum dots was synthesized, characterized, and used as a high capacity adsorbent. A high performance liquid chromatography with UV detector (HPLC-UV) instrument with 58:42 composition of methanol:acetic acid/acetate buffer (pH = 5; 0.05 mol L-1) as the mobile phase and set on the wavelength of 230 nm was used to separate and quantify the analytes. In this regard, different parameters affecting adsorption and desorption of the analytes on the surface of the nanocomposite were studied and optimized to maximize the efficiency of the method. The method was linear in the ranges of 0.5-180 and 0.5-140 ng mL−1 (correlation coefficient (r) > 0.999) with limits of detection of 0.19 and 0.24 ng mL−1 for carbamazepine and phenobarbital, respectively. Eventually, to evaluate the efficiency of the proposed method for the determination of pharmaceuticals in biological samples, different real samples including breast milk, urine and human plasma were tested. Obtained recoveries values were within the range of 96.3 ± 2 to 103.7 ± 3.3% which showed satisfactory efficiency. |
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Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbitalcadmium sulfide quantum dotsreduced graphene oxidemicroextractionpreconcentrationcarbamazepinephenobarbitalThis research presents a fast, sensitive, and selective ultrasound-assisted dispersive solid phase microextraction technique for simultaneous preconcentration and determination of ultra-trace amount of carbamazepine and phenobarbital. Reduced graphene oxide sheets decorated with cadmium sulfide quantum dots was synthesized, characterized, and used as a high capacity adsorbent. A high performance liquid chromatography with UV detector (HPLC-UV) instrument with 58:42 composition of methanol:acetic acid/acetate buffer (pH = 5; 0.05 mol L-1) as the mobile phase and set on the wavelength of 230 nm was used to separate and quantify the analytes. In this regard, different parameters affecting adsorption and desorption of the analytes on the surface of the nanocomposite were studied and optimized to maximize the efficiency of the method. The method was linear in the ranges of 0.5-180 and 0.5-140 ng mL−1 (correlation coefficient (r) > 0.999) with limits of detection of 0.19 and 0.24 ng mL−1 for carbamazepine and phenobarbital, respectively. Eventually, to evaluate the efficiency of the proposed method for the determination of pharmaceuticals in biological samples, different real samples including breast milk, urine and human plasma were tested. Obtained recoveries values were within the range of 96.3 ± 2 to 103.7 ± 3.3% which showed satisfactory efficiency.Sociedade Brasileira de Química2021-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000400833Journal of the Brazilian Chemical Society v.32 n.4 2021reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20200234info:eu-repo/semantics/openAccessShafiee,AliAibaghi,BehzadZhang,Xueng2021-03-25T00:00:00Zoai:scielo:S0103-50532021000400833Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2021-03-25T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbital |
title |
Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbital |
spellingShingle |
Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbital Shafiee,Ali cadmium sulfide quantum dots reduced graphene oxide microextraction preconcentration carbamazepine phenobarbital |
title_short |
Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbital |
title_full |
Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbital |
title_fullStr |
Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbital |
title_full_unstemmed |
Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbital |
title_sort |
Reduced Graphene Oxide-Cadmium Sulfide Quantum Dots Nanocomposite Based Dispersive Solid Phase Microextraction for Ultra-Trace Determination of Carbamazepine and Phenobarbital |
author |
Shafiee,Ali |
author_facet |
Shafiee,Ali Aibaghi,Behzad Zhang,Xu |
author_role |
author |
author2 |
Aibaghi,Behzad Zhang,Xu |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Shafiee,Ali Aibaghi,Behzad Zhang,Xu |
dc.subject.por.fl_str_mv |
cadmium sulfide quantum dots reduced graphene oxide microextraction preconcentration carbamazepine phenobarbital |
topic |
cadmium sulfide quantum dots reduced graphene oxide microextraction preconcentration carbamazepine phenobarbital |
description |
This research presents a fast, sensitive, and selective ultrasound-assisted dispersive solid phase microextraction technique for simultaneous preconcentration and determination of ultra-trace amount of carbamazepine and phenobarbital. Reduced graphene oxide sheets decorated with cadmium sulfide quantum dots was synthesized, characterized, and used as a high capacity adsorbent. A high performance liquid chromatography with UV detector (HPLC-UV) instrument with 58:42 composition of methanol:acetic acid/acetate buffer (pH = 5; 0.05 mol L-1) as the mobile phase and set on the wavelength of 230 nm was used to separate and quantify the analytes. In this regard, different parameters affecting adsorption and desorption of the analytes on the surface of the nanocomposite were studied and optimized to maximize the efficiency of the method. The method was linear in the ranges of 0.5-180 and 0.5-140 ng mL−1 (correlation coefficient (r) > 0.999) with limits of detection of 0.19 and 0.24 ng mL−1 for carbamazepine and phenobarbital, respectively. Eventually, to evaluate the efficiency of the proposed method for the determination of pharmaceuticals in biological samples, different real samples including breast milk, urine and human plasma were tested. Obtained recoveries values were within the range of 96.3 ± 2 to 103.7 ± 3.3% which showed satisfactory efficiency. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000400833 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000400833 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20200234 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.32 n.4 2021 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318183996194816 |