Photodegradation of Fluoxetine Applying Different Photolytic Reactors: Evaluation of the Process Efficiency and Mechanism

• Autor(a) principal: Moreira,Ailton J.
• Data de Publicação: 2019
• Outros Autores: Borges,Aline C., Sousa,Bianca B. de, Mendonça,Vagner R. de, Freschi,Carolina D., Freschi,Gian P. G.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000501010
• topic: fluoxetine; photochemical reactor; transformation products; photolysis; kinetics

Photolytic degradation of fluoxetine (FLX), a medicine commonly known as Prozac®, was evaluated by using different photochemical processes. The ultraviolet/microwave (UV/MW) process showed higher efficiency in all the aspects evaluated in this study. The energy consumption was equivalent to 1.94 × 10-4 kW h mg-1 L (UV/MW), while in the UV process the value was 1.20 × 10-2 kW h mg-1 L. The degradation kinetics were applied to the FLX, with rate constant (k) = 0.15 ± 0.01 min-1 and linear correlation coefficient (R2) = 0.980 for UV, and k = 6.15 ± 0.08 min-1 and R2 = 0.998 for UV/MW. The FLX degradation of 99.16% (UV/MW 5 min) and 98.90% (UV 120 min) were observed, evidencing higher efficiency for the first process. The monitoring of transformation products (TPs) through chromatographic analysis enabled the identification of 9 TPs, proving that for the UV/MW process, the hydroxylated structures are verified in high quantity.