In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES)
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001102163 |
Resumo: | In this study, inductively coupled plasma optical emission spectrometry (ICP OES) was used for multi-element analysis in five multimineral preparations from a dissolution test, in accordance with the United States Pharmacopeia (USP 34 method): apparatus 1, 75 rpm and 900 mL of 0.1 mol L-1 HCl. Element releases in all samples (minimum-maximum in %) were: Ca (14.5-28.2), Cr (54.5-68.0), Cu (2.9-10.0), Fe (4.0-34.3), Mg (6.0-25.2), Mn (2.6-51.2), V (0.0-51.4) and Zn (1.5-107.3). The concentrations of Al, Ba, Cd, Co, Mo, Pb and Se were below the limit of detection of ICP OES. Accuracy was assessed by microwave digestion and recovery values of 94-102%. USP 34 method indicates that not less than 75% of the elements described on the product label must be dissolved in 1 h. Only the release of Zn met the recommendations. The results indicated the need for greater quality control in multivitamin preparations. The dissolution test was validated in order to contribute to Brazilian and other pharmacopoeias. |
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In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES)multimineralmultivitamin preparationsdissolution profilesICP OESIn this study, inductively coupled plasma optical emission spectrometry (ICP OES) was used for multi-element analysis in five multimineral preparations from a dissolution test, in accordance with the United States Pharmacopeia (USP 34 method): apparatus 1, 75 rpm and 900 mL of 0.1 mol L-1 HCl. Element releases in all samples (minimum-maximum in %) were: Ca (14.5-28.2), Cr (54.5-68.0), Cu (2.9-10.0), Fe (4.0-34.3), Mg (6.0-25.2), Mn (2.6-51.2), V (0.0-51.4) and Zn (1.5-107.3). The concentrations of Al, Ba, Cd, Co, Mo, Pb and Se were below the limit of detection of ICP OES. Accuracy was assessed by microwave digestion and recovery values of 94-102%. USP 34 method indicates that not less than 75% of the elements described on the product label must be dissolved in 1 h. Only the release of Zn met the recommendations. The results indicated the need for greater quality control in multivitamin preparations. The dissolution test was validated in order to contribute to Brazilian and other pharmacopoeias.Sociedade Brasileira de Química2017-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001102163Journal of the Brazilian Chemical Society v.28 n.11 2017reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20170065info:eu-repo/semantics/openAccessSantos Júnior,Aníbal de F.Sá,Ramon R.Silva,Laiana O. B.Magalhães,Hemerson I. F.Tarantino,Taiana B.Korn,Maria Graças A.eng2017-10-26T00:00:00Zoai:scielo:S0103-50532017001102163Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2017-10-26T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES) |
title |
In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES) |
spellingShingle |
In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES) Santos Júnior,Aníbal de F. multimineral multivitamin preparations dissolution profiles ICP OES |
title_short |
In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES) |
title_full |
In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES) |
title_fullStr |
In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES) |
title_full_unstemmed |
In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES) |
title_sort |
In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES) |
author |
Santos Júnior,Aníbal de F. |
author_facet |
Santos Júnior,Aníbal de F. Sá,Ramon R. Silva,Laiana O. B. Magalhães,Hemerson I. F. Tarantino,Taiana B. Korn,Maria Graças A. |
author_role |
author |
author2 |
Sá,Ramon R. Silva,Laiana O. B. Magalhães,Hemerson I. F. Tarantino,Taiana B. Korn,Maria Graças A. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos Júnior,Aníbal de F. Sá,Ramon R. Silva,Laiana O. B. Magalhães,Hemerson I. F. Tarantino,Taiana B. Korn,Maria Graças A. |
dc.subject.por.fl_str_mv |
multimineral multivitamin preparations dissolution profiles ICP OES |
topic |
multimineral multivitamin preparations dissolution profiles ICP OES |
description |
In this study, inductively coupled plasma optical emission spectrometry (ICP OES) was used for multi-element analysis in five multimineral preparations from a dissolution test, in accordance with the United States Pharmacopeia (USP 34 method): apparatus 1, 75 rpm and 900 mL of 0.1 mol L-1 HCl. Element releases in all samples (minimum-maximum in %) were: Ca (14.5-28.2), Cr (54.5-68.0), Cu (2.9-10.0), Fe (4.0-34.3), Mg (6.0-25.2), Mn (2.6-51.2), V (0.0-51.4) and Zn (1.5-107.3). The concentrations of Al, Ba, Cd, Co, Mo, Pb and Se were below the limit of detection of ICP OES. Accuracy was assessed by microwave digestion and recovery values of 94-102%. USP 34 method indicates that not less than 75% of the elements described on the product label must be dissolved in 1 h. Only the release of Zn met the recommendations. The results indicated the need for greater quality control in multivitamin preparations. The dissolution test was validated in order to contribute to Brazilian and other pharmacopoeias. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001102163 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001102163 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20170065 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.28 n.11 2017 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318180025237504 |