Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000500023 |
Resumo: | A simple, accurate and precise flow-injection turbidimetric procedure is reported for the determination of acetylcysteine in pharmaceutical formulations. The procedure is based on the precipitation of acetylcysteine with silver nitrate solution in acid medium and the insoluble salt produced was monitored at 410 nm. The analytical curve for acetylcysteine was linear in the concentration range from 1.0 × 10-4 to 1.0 × 10-3 mol L-1 with a detection limit of 5.0 × 10-5 mol L-1. The sampling rate was 60 h-1 and the relative standard deviations (RSDs) were less than 2.0% for 1.0 × 10-4 and 5.0 × 10-4 mol L-1 acetylcysteine solutions (n=10). The recovery of this analyte in four samples ranged from 97.6 to 103 %. A paired t-test showed that all results obtained for acetylcysteine in pharmaceutical products using the proposed flow-injection procedure and the official procedure agreed at the 95% confidence level. |
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Journal of the Brazilian Chemical Society (Online) |
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Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagentflow injectionturbidimetryacetylcysteinepharmaceuticalssilver nitrateA simple, accurate and precise flow-injection turbidimetric procedure is reported for the determination of acetylcysteine in pharmaceutical formulations. The procedure is based on the precipitation of acetylcysteine with silver nitrate solution in acid medium and the insoluble salt produced was monitored at 410 nm. The analytical curve for acetylcysteine was linear in the concentration range from 1.0 × 10-4 to 1.0 × 10-3 mol L-1 with a detection limit of 5.0 × 10-5 mol L-1. The sampling rate was 60 h-1 and the relative standard deviations (RSDs) were less than 2.0% for 1.0 × 10-4 and 5.0 × 10-4 mol L-1 acetylcysteine solutions (n=10). The recovery of this analyte in four samples ranged from 97.6 to 103 %. A paired t-test showed that all results obtained for acetylcysteine in pharmaceutical products using the proposed flow-injection procedure and the official procedure agreed at the 95% confidence level.Sociedade Brasileira de Química2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000500023Journal of the Brazilian Chemical Society v.18 n.5 2007reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532007000500023info:eu-repo/semantics/openAccessSuarez,Willian T.Vieira,Heberth J.Fatibello-Filho,Orlandoeng2007-10-25T00:00:00Zoai:scielo:S0103-50532007000500023Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2007-10-25T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent |
title |
Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent |
spellingShingle |
Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent Suarez,Willian T. flow injection turbidimetry acetylcysteine pharmaceuticals silver nitrate |
title_short |
Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent |
title_full |
Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent |
title_fullStr |
Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent |
title_full_unstemmed |
Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent |
title_sort |
Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent |
author |
Suarez,Willian T. |
author_facet |
Suarez,Willian T. Vieira,Heberth J. Fatibello-Filho,Orlando |
author_role |
author |
author2 |
Vieira,Heberth J. Fatibello-Filho,Orlando |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Suarez,Willian T. Vieira,Heberth J. Fatibello-Filho,Orlando |
dc.subject.por.fl_str_mv |
flow injection turbidimetry acetylcysteine pharmaceuticals silver nitrate |
topic |
flow injection turbidimetry acetylcysteine pharmaceuticals silver nitrate |
description |
A simple, accurate and precise flow-injection turbidimetric procedure is reported for the determination of acetylcysteine in pharmaceutical formulations. The procedure is based on the precipitation of acetylcysteine with silver nitrate solution in acid medium and the insoluble salt produced was monitored at 410 nm. The analytical curve for acetylcysteine was linear in the concentration range from 1.0 × 10-4 to 1.0 × 10-3 mol L-1 with a detection limit of 5.0 × 10-5 mol L-1. The sampling rate was 60 h-1 and the relative standard deviations (RSDs) were less than 2.0% for 1.0 × 10-4 and 5.0 × 10-4 mol L-1 acetylcysteine solutions (n=10). The recovery of this analyte in four samples ranged from 97.6 to 103 %. A paired t-test showed that all results obtained for acetylcysteine in pharmaceutical products using the proposed flow-injection procedure and the official procedure agreed at the 95% confidence level. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000500023 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000500023 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532007000500023 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.18 n.5 2007 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318168200445952 |