Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent

Detalhes bibliográficos
Autor(a) principal: Suarez,Willian T.
Data de Publicação: 2007
Outros Autores: Vieira,Heberth J., Fatibello-Filho,Orlando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000500023
Resumo: A simple, accurate and precise flow-injection turbidimetric procedure is reported for the determination of acetylcysteine in pharmaceutical formulations. The procedure is based on the precipitation of acetylcysteine with silver nitrate solution in acid medium and the insoluble salt produced was monitored at 410 nm. The analytical curve for acetylcysteine was linear in the concentration range from 1.0 × 10-4 to 1.0 × 10-3 mol L-1 with a detection limit of 5.0 × 10-5 mol L-1. The sampling rate was 60 h-1 and the relative standard deviations (RSDs) were less than 2.0% for 1.0 × 10-4 and 5.0 × 10-4 mol L-1 acetylcysteine solutions (n=10). The recovery of this analyte in four samples ranged from 97.6 to 103 %. A paired t-test showed that all results obtained for acetylcysteine in pharmaceutical products using the proposed flow-injection procedure and the official procedure agreed at the 95% confidence level.
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spelling Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagentflow injectionturbidimetryacetylcysteinepharmaceuticalssilver nitrateA simple, accurate and precise flow-injection turbidimetric procedure is reported for the determination of acetylcysteine in pharmaceutical formulations. The procedure is based on the precipitation of acetylcysteine with silver nitrate solution in acid medium and the insoluble salt produced was monitored at 410 nm. The analytical curve for acetylcysteine was linear in the concentration range from 1.0 × 10-4 to 1.0 × 10-3 mol L-1 with a detection limit of 5.0 × 10-5 mol L-1. The sampling rate was 60 h-1 and the relative standard deviations (RSDs) were less than 2.0% for 1.0 × 10-4 and 5.0 × 10-4 mol L-1 acetylcysteine solutions (n=10). The recovery of this analyte in four samples ranged from 97.6 to 103 %. A paired t-test showed that all results obtained for acetylcysteine in pharmaceutical products using the proposed flow-injection procedure and the official procedure agreed at the 95% confidence level.Sociedade Brasileira de Química2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000500023Journal of the Brazilian Chemical Society v.18 n.5 2007reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532007000500023info:eu-repo/semantics/openAccessSuarez,Willian T.Vieira,Heberth J.Fatibello-Filho,Orlandoeng2007-10-25T00:00:00Zoai:scielo:S0103-50532007000500023Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2007-10-25T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent
title Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent
spellingShingle Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent
Suarez,Willian T.
flow injection
turbidimetry
acetylcysteine
pharmaceuticals
silver nitrate
title_short Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent
title_full Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent
title_fullStr Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent
title_full_unstemmed Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent
title_sort Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent
author Suarez,Willian T.
author_facet Suarez,Willian T.
Vieira,Heberth J.
Fatibello-Filho,Orlando
author_role author
author2 Vieira,Heberth J.
Fatibello-Filho,Orlando
author2_role author
author
dc.contributor.author.fl_str_mv Suarez,Willian T.
Vieira,Heberth J.
Fatibello-Filho,Orlando
dc.subject.por.fl_str_mv flow injection
turbidimetry
acetylcysteine
pharmaceuticals
silver nitrate
topic flow injection
turbidimetry
acetylcysteine
pharmaceuticals
silver nitrate
description A simple, accurate and precise flow-injection turbidimetric procedure is reported for the determination of acetylcysteine in pharmaceutical formulations. The procedure is based on the precipitation of acetylcysteine with silver nitrate solution in acid medium and the insoluble salt produced was monitored at 410 nm. The analytical curve for acetylcysteine was linear in the concentration range from 1.0 × 10-4 to 1.0 × 10-3 mol L-1 with a detection limit of 5.0 × 10-5 mol L-1. The sampling rate was 60 h-1 and the relative standard deviations (RSDs) were less than 2.0% for 1.0 × 10-4 and 5.0 × 10-4 mol L-1 acetylcysteine solutions (n=10). The recovery of this analyte in four samples ranged from 97.6 to 103 %. A paired t-test showed that all results obtained for acetylcysteine in pharmaceutical products using the proposed flow-injection procedure and the official procedure agreed at the 95% confidence level.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000500023
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000500023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532007000500023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.18 n.5 2007
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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