Leishmaniasis and Chagas disease chemotherapy: a critical review

Detalhes bibliográficos
Autor(a) principal: Silva-Jardim,Izaltina
Data de Publicação: 2014
Outros Autores: Thiemann,Otavio H., Anibal,Fernanda F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000006
Resumo: Leishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp and Trypanosoma cruzi, respectively, are among the most important parasitic diseases, affecting millions of people and considered to be within the most relevant group of neglected tropical diseases. Chemotherapy is the main alternative to control such parasites, nevertheless, current treatments are far from satisfactory. This review outlines the current understanding on different drugs against leishmaniasis and Chagas disease and their mechanism of action. Recent approaches in the area of anti-leishmanial and trypanocidal therapies are also enumerated, as well as the search for new drugs.
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spelling Leishmaniasis and Chagas disease chemotherapy: a critical reviewVisceral leishmaniasisAmerican tegumentary leishmaniasisChagas diseaseLeishmaniaTrypanosoma cruzichemotherapyLeishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp and Trypanosoma cruzi, respectively, are among the most important parasitic diseases, affecting millions of people and considered to be within the most relevant group of neglected tropical diseases. Chemotherapy is the main alternative to control such parasites, nevertheless, current treatments are far from satisfactory. This review outlines the current understanding on different drugs against leishmaniasis and Chagas disease and their mechanism of action. Recent approaches in the area of anti-leishmanial and trypanocidal therapies are also enumerated, as well as the search for new drugs.Sociedade Brasileira de Química2014-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000006Journal of the Brazilian Chemical Society v.25 n.10 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140229info:eu-repo/semantics/openAccessSilva-Jardim,IzaltinaThiemann,Otavio H.Anibal,Fernanda F.eng2014-10-27T00:00:00Zoai:scielo:S0103-50532014001000006Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-10-27T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Leishmaniasis and Chagas disease chemotherapy: a critical review
title Leishmaniasis and Chagas disease chemotherapy: a critical review
spellingShingle Leishmaniasis and Chagas disease chemotherapy: a critical review
Silva-Jardim,Izaltina
Visceral leishmaniasis
American tegumentary leishmaniasis
Chagas disease
Leishmania
Trypanosoma cruzi
chemotherapy
title_short Leishmaniasis and Chagas disease chemotherapy: a critical review
title_full Leishmaniasis and Chagas disease chemotherapy: a critical review
title_fullStr Leishmaniasis and Chagas disease chemotherapy: a critical review
title_full_unstemmed Leishmaniasis and Chagas disease chemotherapy: a critical review
title_sort Leishmaniasis and Chagas disease chemotherapy: a critical review
author Silva-Jardim,Izaltina
author_facet Silva-Jardim,Izaltina
Thiemann,Otavio H.
Anibal,Fernanda F.
author_role author
author2 Thiemann,Otavio H.
Anibal,Fernanda F.
author2_role author
author
dc.contributor.author.fl_str_mv Silva-Jardim,Izaltina
Thiemann,Otavio H.
Anibal,Fernanda F.
dc.subject.por.fl_str_mv Visceral leishmaniasis
American tegumentary leishmaniasis
Chagas disease
Leishmania
Trypanosoma cruzi
chemotherapy
topic Visceral leishmaniasis
American tegumentary leishmaniasis
Chagas disease
Leishmania
Trypanosoma cruzi
chemotherapy
description Leishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp and Trypanosoma cruzi, respectively, are among the most important parasitic diseases, affecting millions of people and considered to be within the most relevant group of neglected tropical diseases. Chemotherapy is the main alternative to control such parasites, nevertheless, current treatments are far from satisfactory. This review outlines the current understanding on different drugs against leishmaniasis and Chagas disease and their mechanism of action. Recent approaches in the area of anti-leishmanial and trypanocidal therapies are also enumerated, as well as the search for new drugs.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20140229
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.25 n.10 2014
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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