A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study

Detalhes bibliográficos
Autor(a) principal: Ganjali,Mohammad Reza
Data de Publicação: 2009
Outros Autores: Memari,Zahra, Riahi,Siavash, Faridbod,Farnoush, Norouzi,Parviz, Sian,Manesha A. K.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000500018
Resumo: Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is available as the hydrobromide or methylbromide salt. In this study, a potentiometric liquid membrane sensor for simple and fast determination of homatropine hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, homatropine-tetraphenylborate complexes were employed as electroactive materials in the membrane. The proposed sensor presents wide linear range (10-5-10-1 mol L-1), low detection limit (8×10-6 mol L-1), and fast response time (ca. 10 s). Validation of the method shows suitability of the sensors for applicability in the quality control analysis of homatropine hydrobromide in pharmaceutical formulation and urine.
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spelling A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational studypotentiometric sensorPVC membranehomatropine hydrobromidechemometricsdensity functional based tight binding (DFTB)Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is available as the hydrobromide or methylbromide salt. In this study, a potentiometric liquid membrane sensor for simple and fast determination of homatropine hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, homatropine-tetraphenylborate complexes were employed as electroactive materials in the membrane. The proposed sensor presents wide linear range (10-5-10-1 mol L-1), low detection limit (8×10-6 mol L-1), and fast response time (ca. 10 s). Validation of the method shows suitability of the sensors for applicability in the quality control analysis of homatropine hydrobromide in pharmaceutical formulation and urine.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000500018Journal of the Brazilian Chemical Society v.20 n.5 2009reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532009000500018info:eu-repo/semantics/openAccessGanjali,Mohammad RezaMemari,ZahraRiahi,SiavashFaridbod,FarnoushNorouzi,ParvizSian,Manesha A. K.eng2009-06-29T00:00:00Zoai:scielo:S0103-50532009000500018Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2009-06-29T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study
title A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study
spellingShingle A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study
Ganjali,Mohammad Reza
potentiometric sensor
PVC membrane
homatropine hydrobromide
chemometrics
density functional based tight binding (DFTB)
title_short A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study
title_full A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study
title_fullStr A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study
title_full_unstemmed A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study
title_sort A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study
author Ganjali,Mohammad Reza
author_facet Ganjali,Mohammad Reza
Memari,Zahra
Riahi,Siavash
Faridbod,Farnoush
Norouzi,Parviz
Sian,Manesha A. K.
author_role author
author2 Memari,Zahra
Riahi,Siavash
Faridbod,Farnoush
Norouzi,Parviz
Sian,Manesha A. K.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ganjali,Mohammad Reza
Memari,Zahra
Riahi,Siavash
Faridbod,Farnoush
Norouzi,Parviz
Sian,Manesha A. K.
dc.subject.por.fl_str_mv potentiometric sensor
PVC membrane
homatropine hydrobromide
chemometrics
density functional based tight binding (DFTB)
topic potentiometric sensor
PVC membrane
homatropine hydrobromide
chemometrics
density functional based tight binding (DFTB)
description Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is available as the hydrobromide or methylbromide salt. In this study, a potentiometric liquid membrane sensor for simple and fast determination of homatropine hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, homatropine-tetraphenylborate complexes were employed as electroactive materials in the membrane. The proposed sensor presents wide linear range (10-5-10-1 mol L-1), low detection limit (8×10-6 mol L-1), and fast response time (ca. 10 s). Validation of the method shows suitability of the sensors for applicability in the quality control analysis of homatropine hydrobromide in pharmaceutical formulation and urine.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000500018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000500018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532009000500018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.20 n.5 2009
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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