A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000500018 |
Resumo: | Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is available as the hydrobromide or methylbromide salt. In this study, a potentiometric liquid membrane sensor for simple and fast determination of homatropine hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, homatropine-tetraphenylborate complexes were employed as electroactive materials in the membrane. The proposed sensor presents wide linear range (10-5-10-1 mol L-1), low detection limit (8×10-6 mol L-1), and fast response time (ca. 10 s). Validation of the method shows suitability of the sensors for applicability in the quality control analysis of homatropine hydrobromide in pharmaceutical formulation and urine. |
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A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational studypotentiometric sensorPVC membranehomatropine hydrobromidechemometricsdensity functional based tight binding (DFTB)Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is available as the hydrobromide or methylbromide salt. In this study, a potentiometric liquid membrane sensor for simple and fast determination of homatropine hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, homatropine-tetraphenylborate complexes were employed as electroactive materials in the membrane. The proposed sensor presents wide linear range (10-5-10-1 mol L-1), low detection limit (8×10-6 mol L-1), and fast response time (ca. 10 s). Validation of the method shows suitability of the sensors for applicability in the quality control analysis of homatropine hydrobromide in pharmaceutical formulation and urine.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000500018Journal of the Brazilian Chemical Society v.20 n.5 2009reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532009000500018info:eu-repo/semantics/openAccessGanjali,Mohammad RezaMemari,ZahraRiahi,SiavashFaridbod,FarnoushNorouzi,ParvizSian,Manesha A. K.eng2009-06-29T00:00:00Zoai:scielo:S0103-50532009000500018Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2009-06-29T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study |
title |
A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study |
spellingShingle |
A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study Ganjali,Mohammad Reza potentiometric sensor PVC membrane homatropine hydrobromide chemometrics density functional based tight binding (DFTB) |
title_short |
A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study |
title_full |
A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study |
title_fullStr |
A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study |
title_full_unstemmed |
A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study |
title_sort |
A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study |
author |
Ganjali,Mohammad Reza |
author_facet |
Ganjali,Mohammad Reza Memari,Zahra Riahi,Siavash Faridbod,Farnoush Norouzi,Parviz Sian,Manesha A. K. |
author_role |
author |
author2 |
Memari,Zahra Riahi,Siavash Faridbod,Farnoush Norouzi,Parviz Sian,Manesha A. K. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ganjali,Mohammad Reza Memari,Zahra Riahi,Siavash Faridbod,Farnoush Norouzi,Parviz Sian,Manesha A. K. |
dc.subject.por.fl_str_mv |
potentiometric sensor PVC membrane homatropine hydrobromide chemometrics density functional based tight binding (DFTB) |
topic |
potentiometric sensor PVC membrane homatropine hydrobromide chemometrics density functional based tight binding (DFTB) |
description |
Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is available as the hydrobromide or methylbromide salt. In this study, a potentiometric liquid membrane sensor for simple and fast determination of homatropine hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, homatropine-tetraphenylborate complexes were employed as electroactive materials in the membrane. The proposed sensor presents wide linear range (10-5-10-1 mol L-1), low detection limit (8×10-6 mol L-1), and fast response time (ca. 10 s). Validation of the method shows suitability of the sensors for applicability in the quality control analysis of homatropine hydrobromide in pharmaceutical formulation and urine. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000500018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000500018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532009000500018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.20 n.5 2009 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318169866633216 |