Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes

Detalhes bibliográficos
Autor(a) principal: Horta,Lívia P.
Data de Publicação: 2016
Outros Autores: Mota,Yane C. C., Barbosa,Gisele Maria, Braga,Taniris C., Marriel,Ivanildo E., Fátima,Ângelo de, Modolo,Luzia V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801512
Resumo: The plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thiourea (urease inhibitor) core was added to the structure of newly synthesized compounds to provide inhibitors up to 230-fold more active than the PNPs they originated from. The PNP derivatives are mixed inhibitors with higher affinity to urease active site. Two compounds were as efficient as N-(butyl)thiophosphoric triamide (NBPT) toward soil. Overall, PNPs derivatives are promising urease inhibitors for use as additive in urea-based fertilizers formulations.
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spelling Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydesureaurease inhibitornatural productphenolic aldehydefertilizer additiveThe plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thiourea (urease inhibitor) core was added to the structure of newly synthesized compounds to provide inhibitors up to 230-fold more active than the PNPs they originated from. The PNP derivatives are mixed inhibitors with higher affinity to urease active site. Two compounds were as efficient as N-(butyl)thiophosphoric triamide (NBPT) toward soil. Overall, PNPs derivatives are promising urease inhibitors for use as additive in urea-based fertilizers formulations.Sociedade Brasileira de Química2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801512Journal of the Brazilian Chemical Society v.27 n.8 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20160208info:eu-repo/semantics/openAccessHorta,Lívia P.Mota,Yane C. C.Barbosa,Gisele MariaBraga,Taniris C.Marriel,Ivanildo E.Fátima,Ângelo deModolo,Luzia V.eng2016-08-19T00:00:00Zoai:scielo:S0103-50532016000801512Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-08-19T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes
title Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes
spellingShingle Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes
Horta,Lívia P.
urea
urease inhibitor
natural product
phenolic aldehyde
fertilizer additive
title_short Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes
title_full Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes
title_fullStr Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes
title_full_unstemmed Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes
title_sort Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes
author Horta,Lívia P.
author_facet Horta,Lívia P.
Mota,Yane C. C.
Barbosa,Gisele Maria
Braga,Taniris C.
Marriel,Ivanildo E.
Fátima,Ângelo de
Modolo,Luzia V.
author_role author
author2 Mota,Yane C. C.
Barbosa,Gisele Maria
Braga,Taniris C.
Marriel,Ivanildo E.
Fátima,Ângelo de
Modolo,Luzia V.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Horta,Lívia P.
Mota,Yane C. C.
Barbosa,Gisele Maria
Braga,Taniris C.
Marriel,Ivanildo E.
Fátima,Ângelo de
Modolo,Luzia V.
dc.subject.por.fl_str_mv urea
urease inhibitor
natural product
phenolic aldehyde
fertilizer additive
topic urea
urease inhibitor
natural product
phenolic aldehyde
fertilizer additive
description The plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thiourea (urease inhibitor) core was added to the structure of newly synthesized compounds to provide inhibitors up to 230-fold more active than the PNPs they originated from. The PNP derivatives are mixed inhibitors with higher affinity to urease active site. Two compounds were as efficient as N-(butyl)thiophosphoric triamide (NBPT) toward soil. Overall, PNPs derivatives are promising urease inhibitors for use as additive in urea-based fertilizers formulations.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801512
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801512
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0103-5053.20160208
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.27 n.8 2016
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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