Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effects

Detalhes bibliográficos
Autor(a) principal: Amaral,Mônica F. Z. J.
Data de Publicação: 2014
Outros Autores: Callejon,Daniel R., Riul,Thalita B., Baruffi,Marcelo D., Toledo,Fabiano T., Lopes,Norberto P., Clososki,Giuliano C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000016
Resumo: Lignans represent a well-known group of natural products with anti-protozoal activity. In the literature there are many examples of the anti-parasitic activity of synthetic analogues of lignans containing sulphur bridges. In this work, we have obtained thiophene-based analogues by using a selective and high performance synthetic strategy based on the Negishi cross-coupling reaction. The derivatives were quickly obtained and showed great purity, low toxicity toward a mammalian cell line, and leishmanicidal activity with different potencies.
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spelling Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effectsthiopheneleishmanicidalNegishi reactioncross-couplinggreen chemistryLignans represent a well-known group of natural products with anti-protozoal activity. In the literature there are many examples of the anti-parasitic activity of synthetic analogues of lignans containing sulphur bridges. In this work, we have obtained thiophene-based analogues by using a selective and high performance synthetic strategy based on the Negishi cross-coupling reaction. The derivatives were quickly obtained and showed great purity, low toxicity toward a mammalian cell line, and leishmanicidal activity with different potencies.Sociedade Brasileira de Química2014-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000016Journal of the Brazilian Chemical Society v.25 n.10 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140196info:eu-repo/semantics/openAccessAmaral,Mônica F. Z. J.Callejon,Daniel R.Riul,Thalita B.Baruffi,Marcelo D.Toledo,Fabiano T.Lopes,Norberto P.Clososki,Giuliano C.eng2014-10-27T00:00:00Zoai:scielo:S0103-50532014001000016Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-10-27T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effects
title Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effects
spellingShingle Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effects
Amaral,Mônica F. Z. J.
thiophene
leishmanicidal
Negishi reaction
cross-coupling
green chemistry
title_short Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effects
title_full Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effects
title_fullStr Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effects
title_full_unstemmed Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effects
title_sort Application of the Negishi reaction in the synthesis of thiophene-based lignans analogues with leishmanicidal effects
author Amaral,Mônica F. Z. J.
author_facet Amaral,Mônica F. Z. J.
Callejon,Daniel R.
Riul,Thalita B.
Baruffi,Marcelo D.
Toledo,Fabiano T.
Lopes,Norberto P.
Clososki,Giuliano C.
author_role author
author2 Callejon,Daniel R.
Riul,Thalita B.
Baruffi,Marcelo D.
Toledo,Fabiano T.
Lopes,Norberto P.
Clososki,Giuliano C.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Amaral,Mônica F. Z. J.
Callejon,Daniel R.
Riul,Thalita B.
Baruffi,Marcelo D.
Toledo,Fabiano T.
Lopes,Norberto P.
Clososki,Giuliano C.
dc.subject.por.fl_str_mv thiophene
leishmanicidal
Negishi reaction
cross-coupling
green chemistry
topic thiophene
leishmanicidal
Negishi reaction
cross-coupling
green chemistry
description Lignans represent a well-known group of natural products with anti-protozoal activity. In the literature there are many examples of the anti-parasitic activity of synthetic analogues of lignans containing sulphur bridges. In this work, we have obtained thiophene-based analogues by using a selective and high performance synthetic strategy based on the Negishi cross-coupling reaction. The derivatives were quickly obtained and showed great purity, low toxicity toward a mammalian cell line, and leishmanicidal activity with different potencies.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20140196
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.25 n.10 2014
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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