Synthesis of Organotin Substituted Tricyclic Macrodiolides
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000300484 |
Resumo: | The radical addition of triorganotin hydrides, R3SnH (R =n-butyl, phenyl, neophyltin), to four unsaturated diesters of (11R,12R)-9,10-dihydro-9,10-ethaneanthracene-11,12-dimethanol leads to products of cyclohydrostannation with an average yield of around 80%. Whereas the addition of these hydrides to diacrylate and dimethacrylate leads to the expected mixtures containing two and four distereoisomeric cyclized products respectively, the addition to di-2-methyl- and di-2-phenylcinnamate yields only four out of the sixteen possible stereoisomers. The observed high stereoselectivity is consistent with a radical tandem cyclohydrostannation mechanism. Full proton (1H), carbon 13 (13C) and tin 119 (119Sn) nuclear magnetic resonance (NMR) data are given. |
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Synthesis of Organotin Substituted Tricyclic Macrodiolidesorganotin substituted macrodiolidescyclohydrostannationstereoselective tandem cyclizationThe radical addition of triorganotin hydrides, R3SnH (R =n-butyl, phenyl, neophyltin), to four unsaturated diesters of (11R,12R)-9,10-dihydro-9,10-ethaneanthracene-11,12-dimethanol leads to products of cyclohydrostannation with an average yield of around 80%. Whereas the addition of these hydrides to diacrylate and dimethacrylate leads to the expected mixtures containing two and four distereoisomeric cyclized products respectively, the addition to di-2-methyl- and di-2-phenylcinnamate yields only four out of the sixteen possible stereoisomers. The observed high stereoselectivity is consistent with a radical tandem cyclohydrostannation mechanism. Full proton (1H), carbon 13 (13C) and tin 119 (119Sn) nuclear magnetic resonance (NMR) data are given.Sociedade Brasileira de Química2016-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000300484Journal of the Brazilian Chemical Society v.27 n.3 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150275info:eu-repo/semantics/openAccessZacconi,Flavia C.Ocampo,Romina A.Podestá,Julio C.Koll,Liliana C.eng2016-03-10T00:00:00Zoai:scielo:S0103-50532016000300484Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-03-10T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Synthesis of Organotin Substituted Tricyclic Macrodiolides |
title |
Synthesis of Organotin Substituted Tricyclic Macrodiolides |
spellingShingle |
Synthesis of Organotin Substituted Tricyclic Macrodiolides Zacconi,Flavia C. organotin substituted macrodiolides cyclohydrostannation stereoselective tandem cyclization |
title_short |
Synthesis of Organotin Substituted Tricyclic Macrodiolides |
title_full |
Synthesis of Organotin Substituted Tricyclic Macrodiolides |
title_fullStr |
Synthesis of Organotin Substituted Tricyclic Macrodiolides |
title_full_unstemmed |
Synthesis of Organotin Substituted Tricyclic Macrodiolides |
title_sort |
Synthesis of Organotin Substituted Tricyclic Macrodiolides |
author |
Zacconi,Flavia C. |
author_facet |
Zacconi,Flavia C. Ocampo,Romina A. Podestá,Julio C. Koll,Liliana C. |
author_role |
author |
author2 |
Ocampo,Romina A. Podestá,Julio C. Koll,Liliana C. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Zacconi,Flavia C. Ocampo,Romina A. Podestá,Julio C. Koll,Liliana C. |
dc.subject.por.fl_str_mv |
organotin substituted macrodiolides cyclohydrostannation stereoselective tandem cyclization |
topic |
organotin substituted macrodiolides cyclohydrostannation stereoselective tandem cyclization |
description |
The radical addition of triorganotin hydrides, R3SnH (R =n-butyl, phenyl, neophyltin), to four unsaturated diesters of (11R,12R)-9,10-dihydro-9,10-ethaneanthracene-11,12-dimethanol leads to products of cyclohydrostannation with an average yield of around 80%. Whereas the addition of these hydrides to diacrylate and dimethacrylate leads to the expected mixtures containing two and four distereoisomeric cyclized products respectively, the addition to di-2-methyl- and di-2-phenylcinnamate yields only four out of the sixteen possible stereoisomers. The observed high stereoselectivity is consistent with a radical tandem cyclohydrostannation mechanism. Full proton (1H), carbon 13 (13C) and tin 119 (119Sn) nuclear magnetic resonance (NMR) data are given. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000300484 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000300484 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20150275 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.27 n.3 2016 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318178247901184 |