Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studies

Detalhes bibliográficos
Autor(a) principal: Tinoco,Luzineide Wanderley
Data de Publicação: 1999
Outros Autores: Figueroa-Villar,José Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000400005
Resumo: The effects of the changes in sample concentration on the NMR chemical shifts and on the selective and non-selective spin-lattice relaxation rates (R1S and R1NS) of the three isomers of nitrobenzaldeyde guanyl hydrazone (NBGH) pure and with bovine serum albumin (BSA) were measured in solution. The results wereused to determine the correlation times (tauc), showing that the degree of intermolecular drug-drug association varies with the nitro group position on the ring and that this degree of association interferes with the interaction of these drugs with BSA. The results suggest that the degree of drug-drug and drug-BSA association are related to the in vitro anti-Trypanosoma cruzi activity of these compounds.
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spelling Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studiesintermolecular interactionsrelaxation ratescorrelation timesguanyl hydrazonesThe effects of the changes in sample concentration on the NMR chemical shifts and on the selective and non-selective spin-lattice relaxation rates (R1S and R1NS) of the three isomers of nitrobenzaldeyde guanyl hydrazone (NBGH) pure and with bovine serum albumin (BSA) were measured in solution. The results wereused to determine the correlation times (tauc), showing that the degree of intermolecular drug-drug association varies with the nitro group position on the ring and that this degree of association interferes with the interaction of these drugs with BSA. The results suggest that the degree of drug-drug and drug-BSA association are related to the in vitro anti-Trypanosoma cruzi activity of these compounds.Sociedade Brasileira de Química1999-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000400005Journal of the Brazilian Chemical Society v.10 n.4 1999reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50531999000400005info:eu-repo/semantics/openAccessTinoco,Luzineide WanderleyFigueroa-Villar,José Danieleng2001-06-21T00:00:00Zoai:scielo:S0103-50531999000400005Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2001-06-21T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studies
title Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studies
spellingShingle Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studies
Tinoco,Luzineide Wanderley
intermolecular interactions
relaxation rates
correlation times
guanyl hydrazones
title_short Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studies
title_full Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studies
title_fullStr Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studies
title_full_unstemmed Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studies
title_sort Determination of correlation times from selective and non-selective spin-lattice relaxation rates and their use in drug-drug and drug-albumin interaction studies
author Tinoco,Luzineide Wanderley
author_facet Tinoco,Luzineide Wanderley
Figueroa-Villar,José Daniel
author_role author
author2 Figueroa-Villar,José Daniel
author2_role author
dc.contributor.author.fl_str_mv Tinoco,Luzineide Wanderley
Figueroa-Villar,José Daniel
dc.subject.por.fl_str_mv intermolecular interactions
relaxation rates
correlation times
guanyl hydrazones
topic intermolecular interactions
relaxation rates
correlation times
guanyl hydrazones
description The effects of the changes in sample concentration on the NMR chemical shifts and on the selective and non-selective spin-lattice relaxation rates (R1S and R1NS) of the three isomers of nitrobenzaldeyde guanyl hydrazone (NBGH) pure and with bovine serum albumin (BSA) were measured in solution. The results wereused to determine the correlation times (tauc), showing that the degree of intermolecular drug-drug association varies with the nitro group position on the ring and that this degree of association interferes with the interaction of these drugs with BSA. The results suggest that the degree of drug-drug and drug-BSA association are related to the in vitro anti-Trypanosoma cruzi activity of these compounds.
publishDate 1999
dc.date.none.fl_str_mv 1999-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000400005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000400005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50531999000400005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.10 n.4 1999
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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