Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins

Detalhes bibliográficos
Autor(a) principal: Maestrin,Ana Paula J.
Data de Publicação: 2004
Outros Autores: Tedesco,Antonio Cláudio, Neri,Cláudio R., Gandini,Maria Elisa F., Serra,Osvaldo A., Iamamoto,Yassuko
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532004000500016
Resumo: The hydroxynitrophenylporphyrins, 5,10,15,20-tetrakis(2-hydroxy-5-nitrophenyl)porphyrin and 5-mono(carboxyphenyl)-10,15,20-tris(2-hydroxy-5-nitrophenyl)porphyrin described in this work were prepared through Adler's method. These compounds were characterized by ¹H NMR and light absorption and emission spectroscopy in the visible region. In order to demonstrate the involvement of ¹O2 production, the uric (UA) acid test was carried out, which considers the decrease in the absorbance of UA at 293 nm following laser light irradiation of a solution containing UA and a photosensitizer. The results obtained demonstrate that these hydroxynitrophenylporphyrins can be considered as promising photosensitizers in PDT.
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spelling Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrinsporphyrinsphotodynamic therapysinglet oxygenuric acidThe hydroxynitrophenylporphyrins, 5,10,15,20-tetrakis(2-hydroxy-5-nitrophenyl)porphyrin and 5-mono(carboxyphenyl)-10,15,20-tris(2-hydroxy-5-nitrophenyl)porphyrin described in this work were prepared through Adler's method. These compounds were characterized by ¹H NMR and light absorption and emission spectroscopy in the visible region. In order to demonstrate the involvement of ¹O2 production, the uric (UA) acid test was carried out, which considers the decrease in the absorbance of UA at 293 nm following laser light irradiation of a solution containing UA and a photosensitizer. The results obtained demonstrate that these hydroxynitrophenylporphyrins can be considered as promising photosensitizers in PDT.Sociedade Brasileira de Química2004-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532004000500016Journal of the Brazilian Chemical Society v.15 n.5 2004reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532004000500016info:eu-repo/semantics/openAccessMaestrin,Ana Paula J.Tedesco,Antonio CláudioNeri,Cláudio R.Gandini,Maria Elisa F.Serra,Osvaldo A.Iamamoto,Yassukoeng2004-11-10T00:00:00Zoai:scielo:S0103-50532004000500016Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2004-11-10T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins
title Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins
spellingShingle Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins
Maestrin,Ana Paula J.
porphyrins
photodynamic therapy
singlet oxygen
uric acid
title_short Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins
title_full Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins
title_fullStr Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins
title_full_unstemmed Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins
title_sort Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins
author Maestrin,Ana Paula J.
author_facet Maestrin,Ana Paula J.
Tedesco,Antonio Cláudio
Neri,Cláudio R.
Gandini,Maria Elisa F.
Serra,Osvaldo A.
Iamamoto,Yassuko
author_role author
author2 Tedesco,Antonio Cláudio
Neri,Cláudio R.
Gandini,Maria Elisa F.
Serra,Osvaldo A.
Iamamoto,Yassuko
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Maestrin,Ana Paula J.
Tedesco,Antonio Cláudio
Neri,Cláudio R.
Gandini,Maria Elisa F.
Serra,Osvaldo A.
Iamamoto,Yassuko
dc.subject.por.fl_str_mv porphyrins
photodynamic therapy
singlet oxygen
uric acid
topic porphyrins
photodynamic therapy
singlet oxygen
uric acid
description The hydroxynitrophenylporphyrins, 5,10,15,20-tetrakis(2-hydroxy-5-nitrophenyl)porphyrin and 5-mono(carboxyphenyl)-10,15,20-tris(2-hydroxy-5-nitrophenyl)porphyrin described in this work were prepared through Adler's method. These compounds were characterized by ¹H NMR and light absorption and emission spectroscopy in the visible region. In order to demonstrate the involvement of ¹O2 production, the uric (UA) acid test was carried out, which considers the decrease in the absorbance of UA at 293 nm following laser light irradiation of a solution containing UA and a photosensitizer. The results obtained demonstrate that these hydroxynitrophenylporphyrins can be considered as promising photosensitizers in PDT.
publishDate 2004
dc.date.none.fl_str_mv 2004-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532004000500016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532004000500016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532004000500016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.15 n.5 2004
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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