Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry

Detalhes bibliográficos
Autor(a) principal: Quispe,Cristina
Data de Publicação: 2011
Outros Autores: Nachtigall,Fabiane M, Fonseca,Maria Francesca R, Alberici,Rosana M, Astudillo,Luis, Villaseñor,Jorge, Eberlin,Marcos N, Santos,Leonardo S
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000500015
Resumo: The structures of intermediate products of ozone degradation of different pharmaceutical compounds have been studied. Under the conditions employed, complete ozone degradation of nadolol was achieved after 100 min. The degradation products obtained in aqueous solution were characterized by electrospray ionization mass (and tandem mass) spectrometry (ESI-MS and ESI-MS/MS). The proposed mechanism for degradation, ozone attacks at the aniline amino group giving rise to nitro compounds and further degradation occurs via a series of oxidative processes. Continuous online monitoring by ESI-MS(/MS) with high accuracy mass measurements showed that ozone degradation of atenolol (ATE) and acebutolol (ACE) occurs via mechanisms similar to that of nadolol
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spelling Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometryozonationdegradationESI-MSpharmaceutical compoundsreaction mechanismThe structures of intermediate products of ozone degradation of different pharmaceutical compounds have been studied. Under the conditions employed, complete ozone degradation of nadolol was achieved after 100 min. The degradation products obtained in aqueous solution were characterized by electrospray ionization mass (and tandem mass) spectrometry (ESI-MS and ESI-MS/MS). The proposed mechanism for degradation, ozone attacks at the aniline amino group giving rise to nitro compounds and further degradation occurs via a series of oxidative processes. Continuous online monitoring by ESI-MS(/MS) with high accuracy mass measurements showed that ozone degradation of atenolol (ATE) and acebutolol (ACE) occurs via mechanisms similar to that of nadololSociedade Brasileira de Química2011-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000500015Journal of the Brazilian Chemical Society v.22 n.5 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011000500015info:eu-repo/semantics/openAccessQuispe,CristinaNachtigall,Fabiane MFonseca,Maria Francesca RAlberici,Rosana MAstudillo,LuisVillaseñor,JorgeEberlin,Marcos NSantos,Leonardo Seng2011-05-16T00:00:00Zoai:scielo:S0103-50532011000500015Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-05-16T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry
title Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry
spellingShingle Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry
Quispe,Cristina
ozonation
degradation
ESI-MS
pharmaceutical compounds
reaction mechanism
title_short Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry
title_full Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry
title_fullStr Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry
title_full_unstemmed Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry
title_sort Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry
author Quispe,Cristina
author_facet Quispe,Cristina
Nachtigall,Fabiane M
Fonseca,Maria Francesca R
Alberici,Rosana M
Astudillo,Luis
Villaseñor,Jorge
Eberlin,Marcos N
Santos,Leonardo S
author_role author
author2 Nachtigall,Fabiane M
Fonseca,Maria Francesca R
Alberici,Rosana M
Astudillo,Luis
Villaseñor,Jorge
Eberlin,Marcos N
Santos,Leonardo S
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quispe,Cristina
Nachtigall,Fabiane M
Fonseca,Maria Francesca R
Alberici,Rosana M
Astudillo,Luis
Villaseñor,Jorge
Eberlin,Marcos N
Santos,Leonardo S
dc.subject.por.fl_str_mv ozonation
degradation
ESI-MS
pharmaceutical compounds
reaction mechanism
topic ozonation
degradation
ESI-MS
pharmaceutical compounds
reaction mechanism
description The structures of intermediate products of ozone degradation of different pharmaceutical compounds have been studied. Under the conditions employed, complete ozone degradation of nadolol was achieved after 100 min. The degradation products obtained in aqueous solution were characterized by electrospray ionization mass (and tandem mass) spectrometry (ESI-MS and ESI-MS/MS). The proposed mechanism for degradation, ozone attacks at the aniline amino group giving rise to nitro compounds and further degradation occurs via a series of oxidative processes. Continuous online monitoring by ESI-MS(/MS) with high accuracy mass measurements showed that ozone degradation of atenolol (ATE) and acebutolol (ACE) occurs via mechanisms similar to that of nadolol
publishDate 2011
dc.date.none.fl_str_mv 2011-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000500015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000500015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532011000500015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.22 n.5 2011
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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