Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000200286 |
Resumo: | It was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibiotic resistance modifiers. Two chalcones with catecholic moieties were able to strongly decrease the minimum inhibitory concentration (MIC) of methicillin against methicillin-resistant Staphylococcus aureus, increase the antiradical activity and significantly inhibit the human 5-lipoxygenase. Only one of these chalcones was active synergistically with methicillin. Chalcones with methoxyl substituents at different positions displayed the best activities against Cryptococcus neoformans. Only one chalcone showed good activity against the plant pathogenic bacteria Pseudomonas syringae whose half maximal inhibitory concentration (IC50) value (2.5 µg mL-1) was similar to that observed with the antibiotic streptomycin (2.9 µg mL-1). These simple chalcones have safe potential uses in antioxidant, antimicrobial and anti-inflammatory therapies. |
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Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalconesantioxidant activitypolyoxygenated chalconeshuman 5-lipoxygenase inhibitorsantibacterialantifungalIt was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibiotic resistance modifiers. Two chalcones with catecholic moieties were able to strongly decrease the minimum inhibitory concentration (MIC) of methicillin against methicillin-resistant Staphylococcus aureus, increase the antiradical activity and significantly inhibit the human 5-lipoxygenase. Only one of these chalcones was active synergistically with methicillin. Chalcones with methoxyl substituents at different positions displayed the best activities against Cryptococcus neoformans. Only one chalcone showed good activity against the plant pathogenic bacteria Pseudomonas syringae whose half maximal inhibitory concentration (IC50) value (2.5 µg mL-1) was similar to that observed with the antibiotic streptomycin (2.9 µg mL-1). These simple chalcones have safe potential uses in antioxidant, antimicrobial and anti-inflammatory therapies.Sociedade Brasileira de Química2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000200286Journal of the Brazilian Chemical Society v.30 n.2 2019reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20180177info:eu-repo/semantics/openAccessVásquez-Martínez,Yesseny A.Osorio,Mauricio E.San Martín,Diego A.Carvajal,Marcela A.Vergara,Alejandra P.Sanchez,ElizabethRaimondi,MarcelaZacchino,Susana A.Mascayano,CarolinaTorrent,ClaudiaCabezas,FranciscoMejias,SophiaMontoya,MargaritaCortez-San Martín,Marceloeng2019-01-14T00:00:00Zoai:scielo:S0103-50532019000200286Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2019-01-14T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones |
title |
Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones |
spellingShingle |
Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones Vásquez-Martínez,Yesseny A. antioxidant activity polyoxygenated chalcones human 5-lipoxygenase inhibitors antibacterial antifungal |
title_short |
Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones |
title_full |
Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones |
title_fullStr |
Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones |
title_full_unstemmed |
Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones |
title_sort |
Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones |
author |
Vásquez-Martínez,Yesseny A. |
author_facet |
Vásquez-Martínez,Yesseny A. Osorio,Mauricio E. San Martín,Diego A. Carvajal,Marcela A. Vergara,Alejandra P. Sanchez,Elizabeth Raimondi,Marcela Zacchino,Susana A. Mascayano,Carolina Torrent,Claudia Cabezas,Francisco Mejias,Sophia Montoya,Margarita Cortez-San Martín,Marcelo |
author_role |
author |
author2 |
Osorio,Mauricio E. San Martín,Diego A. Carvajal,Marcela A. Vergara,Alejandra P. Sanchez,Elizabeth Raimondi,Marcela Zacchino,Susana A. Mascayano,Carolina Torrent,Claudia Cabezas,Francisco Mejias,Sophia Montoya,Margarita Cortez-San Martín,Marcelo |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Vásquez-Martínez,Yesseny A. Osorio,Mauricio E. San Martín,Diego A. Carvajal,Marcela A. Vergara,Alejandra P. Sanchez,Elizabeth Raimondi,Marcela Zacchino,Susana A. Mascayano,Carolina Torrent,Claudia Cabezas,Francisco Mejias,Sophia Montoya,Margarita Cortez-San Martín,Marcelo |
dc.subject.por.fl_str_mv |
antioxidant activity polyoxygenated chalcones human 5-lipoxygenase inhibitors antibacterial antifungal |
topic |
antioxidant activity polyoxygenated chalcones human 5-lipoxygenase inhibitors antibacterial antifungal |
description |
It was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibiotic resistance modifiers. Two chalcones with catecholic moieties were able to strongly decrease the minimum inhibitory concentration (MIC) of methicillin against methicillin-resistant Staphylococcus aureus, increase the antiradical activity and significantly inhibit the human 5-lipoxygenase. Only one of these chalcones was active synergistically with methicillin. Chalcones with methoxyl substituents at different positions displayed the best activities against Cryptococcus neoformans. Only one chalcone showed good activity against the plant pathogenic bacteria Pseudomonas syringae whose half maximal inhibitory concentration (IC50) value (2.5 µg mL-1) was similar to that observed with the antibiotic streptomycin (2.9 µg mL-1). These simple chalcones have safe potential uses in antioxidant, antimicrobial and anti-inflammatory therapies. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000200286 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000200286 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20180177 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.30 n.2 2019 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318181346443264 |