Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021001202206 |
Resumo: | Dipteryx alata Vogel is a native fruit from Brazil, which has been poorly investigated concerning its phenolic composition and the biological effects of its pulp + peel. Thus, in this study we evaluated the antioxidant activity and total phenolic content of the D. alata pulp + peel extracts obtained with different solvents, as well as determined the phenolic compounds by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) analysis. In addition, cytotoxic effects of D. alata pulp + peel extract on non-tumor and cancer cell lines were investigated for the first time. The results showed that phenolic compounds can be efficiently extracted from pulp + peel of D. alata by organic solvent-water mixtures as an extraction system. The developed UHPLC-MS/MS method allowed the quantification of eighteen phenolic compounds in D. alata pulp + peel extract for the first time, which luteolin and trans-cinnamic acid were predominant. In addition, D. alata pulp + peel extract exhibited better cytotoxity against SiHa and C33A cervical cancer cell lines, while weak cytotoxicity was noticed against non-tumor HaCaT and L929 cell lines, pointing out its safety and providing preliminary evidence of its anticancer potential. Our findings indicate that D. alata pulp + peel can be explored as a natural source of phenolic compounds with promising antioxidant and cytotoxic properties. |
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Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic PropertiesCerrado fruitsbaruphenolic compounds extractionUHPLC-MS/MSMTT assayDipteryx alata Vogel is a native fruit from Brazil, which has been poorly investigated concerning its phenolic composition and the biological effects of its pulp + peel. Thus, in this study we evaluated the antioxidant activity and total phenolic content of the D. alata pulp + peel extracts obtained with different solvents, as well as determined the phenolic compounds by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) analysis. In addition, cytotoxic effects of D. alata pulp + peel extract on non-tumor and cancer cell lines were investigated for the first time. The results showed that phenolic compounds can be efficiently extracted from pulp + peel of D. alata by organic solvent-water mixtures as an extraction system. The developed UHPLC-MS/MS method allowed the quantification of eighteen phenolic compounds in D. alata pulp + peel extract for the first time, which luteolin and trans-cinnamic acid were predominant. In addition, D. alata pulp + peel extract exhibited better cytotoxity against SiHa and C33A cervical cancer cell lines, while weak cytotoxicity was noticed against non-tumor HaCaT and L929 cell lines, pointing out its safety and providing preliminary evidence of its anticancer potential. Our findings indicate that D. alata pulp + peel can be explored as a natural source of phenolic compounds with promising antioxidant and cytotoxic properties.Sociedade Brasileira de Química2021-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021001202206Journal of the Brazilian Chemical Society v.32 n.12 2021reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20210112info:eu-repo/semantics/openAccessBarizão,Érica OBoeing,Joana SRotta,Eliza MVolpato,HélitoNakamura,Celso VMaldaner,LianeVisentainer,Jesuí Veng2021-11-24T00:00:00Zoai:scielo:S0103-50532021001202206Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2021-11-24T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties |
title |
Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties |
spellingShingle |
Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties Barizão,Érica O Cerrado fruits baru phenolic compounds extraction UHPLC-MS/MS MTT assay |
title_short |
Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties |
title_full |
Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties |
title_fullStr |
Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties |
title_full_unstemmed |
Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties |
title_sort |
Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties |
author |
Barizão,Érica O |
author_facet |
Barizão,Érica O Boeing,Joana S Rotta,Eliza M Volpato,Hélito Nakamura,Celso V Maldaner,Liane Visentainer,Jesuí V |
author_role |
author |
author2 |
Boeing,Joana S Rotta,Eliza M Volpato,Hélito Nakamura,Celso V Maldaner,Liane Visentainer,Jesuí V |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Barizão,Érica O Boeing,Joana S Rotta,Eliza M Volpato,Hélito Nakamura,Celso V Maldaner,Liane Visentainer,Jesuí V |
dc.subject.por.fl_str_mv |
Cerrado fruits baru phenolic compounds extraction UHPLC-MS/MS MTT assay |
topic |
Cerrado fruits baru phenolic compounds extraction UHPLC-MS/MS MTT assay |
description |
Dipteryx alata Vogel is a native fruit from Brazil, which has been poorly investigated concerning its phenolic composition and the biological effects of its pulp + peel. Thus, in this study we evaluated the antioxidant activity and total phenolic content of the D. alata pulp + peel extracts obtained with different solvents, as well as determined the phenolic compounds by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) analysis. In addition, cytotoxic effects of D. alata pulp + peel extract on non-tumor and cancer cell lines were investigated for the first time. The results showed that phenolic compounds can be efficiently extracted from pulp + peel of D. alata by organic solvent-water mixtures as an extraction system. The developed UHPLC-MS/MS method allowed the quantification of eighteen phenolic compounds in D. alata pulp + peel extract for the first time, which luteolin and trans-cinnamic acid were predominant. In addition, D. alata pulp + peel extract exhibited better cytotoxity against SiHa and C33A cervical cancer cell lines, while weak cytotoxicity was noticed against non-tumor HaCaT and L929 cell lines, pointing out its safety and providing preliminary evidence of its anticancer potential. Our findings indicate that D. alata pulp + peel can be explored as a natural source of phenolic compounds with promising antioxidant and cytotoxic properties. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021001202206 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021001202206 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20210112 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.32 n.12 2021 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318184484831232 |