Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine

Detalhes bibliográficos
Autor(a) principal: Santos,Vanessa G. dos
Data de Publicação: 2012
Outros Autores: Alves,Ricardo J., Eberlin,Marcos N., Pianetti,Gerson A., César,Isabela C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000100010
Resumo: Electrospray ionization in the positive ion mode and high resolution and high accuracy tandem mass spectrometry performed in a hybrid quadrupole time-of-flight mass spectrometer were used to investigate the dissociation chemistry of the intact molecules of two most widely used antimalarial drugs: artemether and lumefantrine. The dissociation pathways of their cationized and protonated forms were rationalized based on high accuracy mass measurements and isotopic distributions. The obtained results should benefit LC-MS/MS monitoring and quantitation by mass spectrometry of the artemether and lumefantrine molecules, as well as of new derivatives or other structurally related antimalarial drugs.
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spelling Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrineartemetherlumefantrineion dissociationtandem mass spectrometryESI-MS/MSElectrospray ionization in the positive ion mode and high resolution and high accuracy tandem mass spectrometry performed in a hybrid quadrupole time-of-flight mass spectrometer were used to investigate the dissociation chemistry of the intact molecules of two most widely used antimalarial drugs: artemether and lumefantrine. The dissociation pathways of their cationized and protonated forms were rationalized based on high accuracy mass measurements and isotopic distributions. The obtained results should benefit LC-MS/MS monitoring and quantitation by mass spectrometry of the artemether and lumefantrine molecules, as well as of new derivatives or other structurally related antimalarial drugs.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000100010Journal of the Brazilian Chemical Society v.23 n.1 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012000100010info:eu-repo/semantics/openAccessSantos,Vanessa G. dosAlves,Ricardo J.Eberlin,Marcos N.Pianetti,Gerson A.César,Isabela C.eng2012-02-02T00:00:00Zoai:scielo:S0103-50532012000100010Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-02-02T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine
title Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine
spellingShingle Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine
Santos,Vanessa G. dos
artemether
lumefantrine
ion dissociation
tandem mass spectrometry
ESI-MS/MS
title_short Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine
title_full Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine
title_fullStr Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine
title_full_unstemmed Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine
title_sort Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine
author Santos,Vanessa G. dos
author_facet Santos,Vanessa G. dos
Alves,Ricardo J.
Eberlin,Marcos N.
Pianetti,Gerson A.
César,Isabela C.
author_role author
author2 Alves,Ricardo J.
Eberlin,Marcos N.
Pianetti,Gerson A.
César,Isabela C.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos,Vanessa G. dos
Alves,Ricardo J.
Eberlin,Marcos N.
Pianetti,Gerson A.
César,Isabela C.
dc.subject.por.fl_str_mv artemether
lumefantrine
ion dissociation
tandem mass spectrometry
ESI-MS/MS
topic artemether
lumefantrine
ion dissociation
tandem mass spectrometry
ESI-MS/MS
description Electrospray ionization in the positive ion mode and high resolution and high accuracy tandem mass spectrometry performed in a hybrid quadrupole time-of-flight mass spectrometer were used to investigate the dissociation chemistry of the intact molecules of two most widely used antimalarial drugs: artemether and lumefantrine. The dissociation pathways of their cationized and protonated forms were rationalized based on high accuracy mass measurements and isotopic distributions. The obtained results should benefit LC-MS/MS monitoring and quantitation by mass spectrometry of the artemether and lumefantrine molecules, as well as of new derivatives or other structurally related antimalarial drugs.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000100010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000100010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532012000100010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.23 n.1 2012
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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