Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000100010 |
Resumo: | Electrospray ionization in the positive ion mode and high resolution and high accuracy tandem mass spectrometry performed in a hybrid quadrupole time-of-flight mass spectrometer were used to investigate the dissociation chemistry of the intact molecules of two most widely used antimalarial drugs: artemether and lumefantrine. The dissociation pathways of their cationized and protonated forms were rationalized based on high accuracy mass measurements and isotopic distributions. The obtained results should benefit LC-MS/MS monitoring and quantitation by mass spectrometry of the artemether and lumefantrine molecules, as well as of new derivatives or other structurally related antimalarial drugs. |
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Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrineartemetherlumefantrineion dissociationtandem mass spectrometryESI-MS/MSElectrospray ionization in the positive ion mode and high resolution and high accuracy tandem mass spectrometry performed in a hybrid quadrupole time-of-flight mass spectrometer were used to investigate the dissociation chemistry of the intact molecules of two most widely used antimalarial drugs: artemether and lumefantrine. The dissociation pathways of their cationized and protonated forms were rationalized based on high accuracy mass measurements and isotopic distributions. The obtained results should benefit LC-MS/MS monitoring and quantitation by mass spectrometry of the artemether and lumefantrine molecules, as well as of new derivatives or other structurally related antimalarial drugs.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000100010Journal of the Brazilian Chemical Society v.23 n.1 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012000100010info:eu-repo/semantics/openAccessSantos,Vanessa G. dosAlves,Ricardo J.Eberlin,Marcos N.Pianetti,Gerson A.César,Isabela C.eng2012-02-02T00:00:00Zoai:scielo:S0103-50532012000100010Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-02-02T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine |
title |
Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine |
spellingShingle |
Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine Santos,Vanessa G. dos artemether lumefantrine ion dissociation tandem mass spectrometry ESI-MS/MS |
title_short |
Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine |
title_full |
Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine |
title_fullStr |
Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine |
title_full_unstemmed |
Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine |
title_sort |
Electrospray ionization tandem mass spectrometry of the two main antimalarial drugs: artemether and lumefantrine |
author |
Santos,Vanessa G. dos |
author_facet |
Santos,Vanessa G. dos Alves,Ricardo J. Eberlin,Marcos N. Pianetti,Gerson A. César,Isabela C. |
author_role |
author |
author2 |
Alves,Ricardo J. Eberlin,Marcos N. Pianetti,Gerson A. César,Isabela C. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos,Vanessa G. dos Alves,Ricardo J. Eberlin,Marcos N. Pianetti,Gerson A. César,Isabela C. |
dc.subject.por.fl_str_mv |
artemether lumefantrine ion dissociation tandem mass spectrometry ESI-MS/MS |
topic |
artemether lumefantrine ion dissociation tandem mass spectrometry ESI-MS/MS |
description |
Electrospray ionization in the positive ion mode and high resolution and high accuracy tandem mass spectrometry performed in a hybrid quadrupole time-of-flight mass spectrometer were used to investigate the dissociation chemistry of the intact molecules of two most widely used antimalarial drugs: artemether and lumefantrine. The dissociation pathways of their cationized and protonated forms were rationalized based on high accuracy mass measurements and isotopic distributions. The obtained results should benefit LC-MS/MS monitoring and quantitation by mass spectrometry of the artemether and lumefantrine molecules, as well as of new derivatives or other structurally related antimalarial drugs. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000100010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000100010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532012000100010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.23 n.1 2012 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318173053255680 |