Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp.
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000100029 |
Resumo: | The biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus Phomopsis sp, obtained from Viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy-tetrahydrofuran. The metabolite was evaluated against the parasite Trypanosoma cruzi, the causative agent of Chagas's disease, and showed a trypanocidal activity (IC50 9.8 μmol L-1) similar to the natural precursor (IC50 3.7 μmol L-1). |
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Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp.biotransformation2,5-diaryltetrahydrofuranendophytic fungus(-)-grandisintrypanocidal activityThe biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus Phomopsis sp, obtained from Viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy-tetrahydrofuran. The metabolite was evaluated against the parasite Trypanosoma cruzi, the causative agent of Chagas's disease, and showed a trypanocidal activity (IC50 9.8 μmol L-1) similar to the natural precursor (IC50 3.7 μmol L-1).Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000100029Journal of the Brazilian Chemical Society v.20 n.1 2009reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532009000100029info:eu-repo/semantics/openAccessVerza,MichelleArakawa,Nilton S.Lopes,Norberto P.Kato,Massuo J.Pupo,Mônica T.Said,SuraiaCarvalho,Ivoneeng2009-01-15T00:00:00Zoai:scielo:S0103-50532009000100029Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2009-01-15T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp. |
title |
Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp. |
spellingShingle |
Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp. Verza,Michelle biotransformation 2,5-diaryltetrahydrofuran endophytic fungus (-)-grandisin trypanocidal activity |
title_short |
Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp. |
title_full |
Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp. |
title_fullStr |
Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp. |
title_full_unstemmed |
Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp. |
title_sort |
Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp. |
author |
Verza,Michelle |
author_facet |
Verza,Michelle Arakawa,Nilton S. Lopes,Norberto P. Kato,Massuo J. Pupo,Mônica T. Said,Suraia Carvalho,Ivone |
author_role |
author |
author2 |
Arakawa,Nilton S. Lopes,Norberto P. Kato,Massuo J. Pupo,Mônica T. Said,Suraia Carvalho,Ivone |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Verza,Michelle Arakawa,Nilton S. Lopes,Norberto P. Kato,Massuo J. Pupo,Mônica T. Said,Suraia Carvalho,Ivone |
dc.subject.por.fl_str_mv |
biotransformation 2,5-diaryltetrahydrofuran endophytic fungus (-)-grandisin trypanocidal activity |
topic |
biotransformation 2,5-diaryltetrahydrofuran endophytic fungus (-)-grandisin trypanocidal activity |
description |
The biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus Phomopsis sp, obtained from Viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy-tetrahydrofuran. The metabolite was evaluated against the parasite Trypanosoma cruzi, the causative agent of Chagas's disease, and showed a trypanocidal activity (IC50 9.8 μmol L-1) similar to the natural precursor (IC50 3.7 μmol L-1). |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000100029 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000100029 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532009000100029 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.20 n.1 2009 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318169457688576 |