Electrochemical Behavior and Determination of Fluconazole

Detalhes bibliográficos
Autor(a) principal: Gil,Éric de S.
Data de Publicação: 2011
Outros Autores: Cordeiro,Diogo D., Matias,Ana E. B., Serrano,Sílvia H. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000400021
Resumo: The electrochemical behavior of fluconazole showed an irreversible oxidation process, with the electrochemical - chemical mechanism being highly dependent on the electrode material. Adsorption of reagent at positive applied potential was observed at Pt electrode while preferential adsorption of the oxidation products was observed at Glassy Carbon surfaces. In pH below 7.0, the anodic current process was intensively decreased. At carbon paste electrode, the fluconazole oxidation current, recorded in phosphate buffer solution (pH 8.0), changed linearly with the fluconazole concentration, Ipa = 5.7×10-5 (mA) × 0.052 [Fluconazol] (μg mL-1), in the range of 48.0 to 250.0 μg mL-1. The detection limit obtained was 6.3 μg mL-1.
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spelling Electrochemical Behavior and Determination of Fluconazolefluconazoleelectrochemical behaviorvoltammetryelectrodic materialThe electrochemical behavior of fluconazole showed an irreversible oxidation process, with the electrochemical - chemical mechanism being highly dependent on the electrode material. Adsorption of reagent at positive applied potential was observed at Pt electrode while preferential adsorption of the oxidation products was observed at Glassy Carbon surfaces. In pH below 7.0, the anodic current process was intensively decreased. At carbon paste electrode, the fluconazole oxidation current, recorded in phosphate buffer solution (pH 8.0), changed linearly with the fluconazole concentration, Ipa = 5.7×10-5 (mA) × 0.052 [Fluconazol] (μg mL-1), in the range of 48.0 to 250.0 μg mL-1. The detection limit obtained was 6.3 μg mL-1.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000400021Journal of the Brazilian Chemical Society v.22 n.4 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011000400021info:eu-repo/semantics/openAccessGil,Éric de S.Cordeiro,Diogo D.Matias,Ana E. B.Serrano,Sílvia H. P.eng2011-04-14T00:00:00Zoai:scielo:S0103-50532011000400021Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-04-14T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Electrochemical Behavior and Determination of Fluconazole
title Electrochemical Behavior and Determination of Fluconazole
spellingShingle Electrochemical Behavior and Determination of Fluconazole
Gil,Éric de S.
fluconazole
electrochemical behavior
voltammetry
electrodic material
title_short Electrochemical Behavior and Determination of Fluconazole
title_full Electrochemical Behavior and Determination of Fluconazole
title_fullStr Electrochemical Behavior and Determination of Fluconazole
title_full_unstemmed Electrochemical Behavior and Determination of Fluconazole
title_sort Electrochemical Behavior and Determination of Fluconazole
author Gil,Éric de S.
author_facet Gil,Éric de S.
Cordeiro,Diogo D.
Matias,Ana E. B.
Serrano,Sílvia H. P.
author_role author
author2 Cordeiro,Diogo D.
Matias,Ana E. B.
Serrano,Sílvia H. P.
author2_role author
author
author
dc.contributor.author.fl_str_mv Gil,Éric de S.
Cordeiro,Diogo D.
Matias,Ana E. B.
Serrano,Sílvia H. P.
dc.subject.por.fl_str_mv fluconazole
electrochemical behavior
voltammetry
electrodic material
topic fluconazole
electrochemical behavior
voltammetry
electrodic material
description The electrochemical behavior of fluconazole showed an irreversible oxidation process, with the electrochemical - chemical mechanism being highly dependent on the electrode material. Adsorption of reagent at positive applied potential was observed at Pt electrode while preferential adsorption of the oxidation products was observed at Glassy Carbon surfaces. In pH below 7.0, the anodic current process was intensively decreased. At carbon paste electrode, the fluconazole oxidation current, recorded in phosphate buffer solution (pH 8.0), changed linearly with the fluconazole concentration, Ipa = 5.7×10-5 (mA) × 0.052 [Fluconazol] (μg mL-1), in the range of 48.0 to 250.0 μg mL-1. The detection limit obtained was 6.3 μg mL-1.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000400021
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532011000400021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.22 n.4 2011
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
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instname_str Sociedade Brasileira de Química (SBQ)
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institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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